Ignite Creation Date:
2024-05-06 @ 8:28 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06392308
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-02
First Post:
2024-04-26
Brief Title:
The Impact of Smoking on the Prognosis of Elderly Surgical Patients
Sponsor:
Affiliated Hospital of Nantong University
Organization:
Affiliated Hospital of Nantong University
Study Overview
Official Title:
The Impact of Smoking on Postoperative Delirium and Recovery Quality in Elderly Surgical Patients
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Postoperative delirium is a common complication that frequently occurs in elderly patients after surgery It not only increases the length of hospital stays and healthcare costs but also raises the incidence of postoperative cognitive dysfunction and even mortality However the underlying mechanisms of its onset are not yet fully understood Evidence suggests that smoking can lead to gut microbiota dysbiosis and metabolic dysfunction and the gut microbiota and its metabolites play a crucial role in cognitive function through the gut-brain axis Yet no studies have reported whether smoking could affect the occurrence of postoperative delirium and the quality of postoperative recovery through the gut microbiota This study aims to observe the incidence of postoperative delirium and the postoperative recovery quality scores between smokers and non-smokers
Detailed Description:
After obtaining approval from the ethics committee patients are recruited informed of the trial process and potential risks and their informed consent is obtained and signed According to the WHO definition patients are classified into smokers defined as those who smoke more than one cigarette per day continuously or cumulatively for six months more than four times a week but averaging less than one cigarette per day and non-smokers never smoked Fecal and blood samples are collected from both groups of patients preoperatively and perioperative data is gathered Postoperatively an uninformed observer assesses the patients for delirium and recovery quality
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None