Ignite Creation Date:
2024-05-06 @ 8:28 PM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06392152
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-04-30
First Post:
2024-04-24
Brief Title:
Efficacy of Focal Primaquine Mass Administration for Eliminating Plasmodium Vivax Malaria in Northern Myanmar
Sponsor:
Pyae Linn Aung
Organization:
Myanmar Health Network Organization
Study Overview
Official Title:
G6PD Deficiency Prevalence and Targeted Elimination of Residual Plasmodium Vivax Hypnozoites in Community Township Level Implementation in Banmauk and Moe Mauk Myanmar
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Plasmodium vivax has become the predominant species in the Greater Mekong Subregion and is a major challenge for regional malaria elimination Mass primaquine administration has played a decisive role in malaria elimination in many temperate zone countries but its efficacy in tropical areas remains to be evaluated This study aims to assess the efficacy of targeted primaquine mass treatment TPT for eliminating P vivax malaria in northern Myanmar
Detailed Description:
This study employed a cluster-randomized crossover design in which two groups of villages received TPT at different times In August-September 2019 Group 1 received TPT 025 mgkgday primaquine base for 14 days while Group 2 was the control In June-July 2020 Group 2 received TPT while Group 1 served as the control To evaluate the effectiveness of TPT for preventing relapses of vivax malaria two indicators were utilized infection prevalence at 3-month intervals estimated through cross-sectional surveys and monthly malaria incidence by passive case detection The data were analyzed using descriptive statistics chi-squared test cumulative hazard function and mixed model logistic regression
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None