Ignite Creation Date:
2024-05-11 @ 8:30 AM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06400524
Status:
RECRUITING
Last Update Posted:
2024-05-06
First Post:
2024-05-01
Brief Title:
Assessment of Cardiac Function Microvascular Function and Cardiac Perfusion in Different Disease Stages of Hypertrophic Cardiomyopathy
Sponsor:
Amsterdam UMC location VUmc
Organization:
Amsterdam UMC location VUmc
Study Overview
Official Title:
Assessment of Myocardial Function Peripheral Endothelial Function and Perfusion in Early and Advanced Disease Stages of Hypertrophic Cardiomyopathy
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
FUSION-HCM
Brief Summary:
Hypertrophic cardiomyopathy HCM is a genetic disorder characterized by asymmetric hypertrophy of the heart in absence of loading conditions like hypertension The genetic mutation underlying HCM sets in motion a cascade of functional and metabolic changes ultimately leading to disease HCM patients often have microvascular dysfunction and myocardial perfusion deficits of which the aetiology has not been elucidated Whether these changes are secondary to remodelling or primarily caused by endothelial dysfunction is unclear As the pathomechanism of HCM is thought to be a cascade of changes it is important to gain more insight in the perfusion and endothelial function changes throughout different stages of disease no phenotype mild phenotype and advanced HCM phenotype In this study we aim to investigate these changes in the two most common genetic mutations
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None