Ignite Creation Date:
2024-05-11 @ 8:30 AM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06401902
Status:
COMPLETED
Last Update Posted:
2024-05-07
First Post:
2024-05-02
Brief Title:
Diabetes and Risk of Ischemic Stroke
Sponsor:
Institut Mutualiste Montsouris
Organization:
Institut Mutualiste Montsouris
Study Overview
Official Title:
Diabetes and Stroke Does an Excess Risk of Hemodynamic Cerebral Ischemia Exist
Status:
COMPLETED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Diabetes in an independent risk factor for ischemic stroke whose associated mortality rate is higher and sequelae more serious than for nondiabetics Diabetes increases the risk of stroke or death after surgical carotid revascularization or endoluminal angioplasty It is with contralateral ICA occlusion 1 of the 7 factors doubling the stroke risk after carotid endarterectomy Diabetes also enhances the cerebral hemorrhage risk associated with carotid surgery thrombectomy or thrombolysis revascularization of the cerebral arteries
This study was undertaken to examine whether the hemodynamic cerebral ischemia HCI frequency which increases stroke severity is higher in diabetics than nondiabetics and if diabetes carries an excess HCI risk whether it is independent of contralateral ICA occlusion
This study was undertaken to examine whether the hemodynamic cerebral ischemia HCI frequency which increases stroke severity is higher in diabetics than nondiabetics and if diabetes carries an excess HCI risk whether it is independent of contralateral ICA occlusion
Detailed Description:
Embolic and hemodynamic mechanisms are the main causes underlying ischemic strokes of carotid origin The hemodynamic cerebral ischemia HCI risk depends on the contribution of the contralateral internal carotid artery ICA and vertebral arteries via the circle of Willis the ipsilateral external carotid artery via the ophthalmic artery and the leptomeningeal arteries During carotid surgery impaired collateral flow is associated with the need for shunt insertion
When HCI is present cerebral perfusion is initially maintained by vasodilation of precapillary arterioles and the increased extraction coefficient of oxygen Secondarily vascular reserve exhaustion by degradation of arterial lesions engenders a loss of cerebral autoregulation ischemic penumbra and cerebral infarction
Carotid revascularization with an incomplete circle of Willis enhances the postoperative ischemic stroke risk The loss of cerebral autoregulation attributable to HCI combined with ipsilateral carotid tight stenosis heightens the risk of hyperperfusion and cerebral hemorrhage
Carotid occlusion is the primary cause of HCI Carotid occlusions and tight stenoses lead to loss of cerebral autoregulation and cerebrovascular reserve and have been associated with a 4-fold-increased stroke risk
Diabetes in an independent risk factor for ischemic stroke whose associated mortality rate is higher and sequelae more serious than for nondiabetics Diabetes increases the risk of stroke or death after surgical carotid revascularization or endoluminal angioplastyIt is with contralateral ICA occlusion 1 of the 7 factors doubling the stroke risk after carotid endarterectomy Diabetes also enhances the cerebral hemorrhage risk associated with carotid surgery thrombectomy or thrombolysis revascularization of the cerebral arteries
This study was undertaken to examine whether the HCI frequency is higher in diabetics than nondiabetics and if diabetes carries an excess HCI risk whether it is independent of contralateral ICA occlusion
When HCI is present cerebral perfusion is initially maintained by vasodilation of precapillary arterioles and the increased extraction coefficient of oxygen Secondarily vascular reserve exhaustion by degradation of arterial lesions engenders a loss of cerebral autoregulation ischemic penumbra and cerebral infarction
Carotid revascularization with an incomplete circle of Willis enhances the postoperative ischemic stroke risk The loss of cerebral autoregulation attributable to HCI combined with ipsilateral carotid tight stenosis heightens the risk of hyperperfusion and cerebral hemorrhage
Carotid occlusion is the primary cause of HCI Carotid occlusions and tight stenoses lead to loss of cerebral autoregulation and cerebrovascular reserve and have been associated with a 4-fold-increased stroke risk
Diabetes in an independent risk factor for ischemic stroke whose associated mortality rate is higher and sequelae more serious than for nondiabetics Diabetes increases the risk of stroke or death after surgical carotid revascularization or endoluminal angioplastyIt is with contralateral ICA occlusion 1 of the 7 factors doubling the stroke risk after carotid endarterectomy Diabetes also enhances the cerebral hemorrhage risk associated with carotid surgery thrombectomy or thrombolysis revascularization of the cerebral arteries
This study was undertaken to examine whether the HCI frequency is higher in diabetics than nondiabetics and if diabetes carries an excess HCI risk whether it is independent of contralateral ICA occlusion
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None