Ignite Creation Date:
2024-05-11 @ 8:30 AM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06404606
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-03
First Post:
2024-05-05
Brief Title:
Effects of Black Cumin and Turmeric Along With Quantum Acoustic Waves on Inflammatory Markers and Pain in Osteoarthritis
Sponsor:
Pakistan Society for Rehabilitation of Differently Abled Hospital
Organization:
Pakistan Society for Rehabilitation of Differently Abled Hospital
Study Overview
Official Title:
Effects of Black Cumin and Turmeric Along With Quantum Acoustic Waves on Inflammatory Markers and Pain in Osteoarthritis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Osteoarthritis is a chronic inflammatory disease that directly affects the quality of life and financial burden The understanding of the mechanism and available intervention strategies can not minimize its incidence that increased by 110 since 1990 The combination of black cumin and turmeric with sound waves is not well known
Detailed Description:
Osteoarthritis OA is characterized by insult of the joint involving structural and functional modifications including cartilage rupture bone deterioration and spur formation presented with pain inflammation joint functional limitation It is estimated that incidence of osteoarthritis is around 20 Indeed it is estimated that incidence is higher in Asia and middle east countries 16-29 as compared to Europe 10-17 and north America 12-21 The aggravating symptoms progress and ultimately cause disability decline quality of life and put economic burden Various factors involve in the pathophysiology of OA such as mechanical inflammatory metabolic ageing and genetics that causing structural change and functional limitation along with chronic pain Nevertheless there are advancement happening about understanding of the basic mechanism of OA However low grade inflammation of the synovial lining is currently considered a major contributing factor that play essential role in understanding the pathophysiology Moreover adaptive central immunological mechanism is recognized pivotal in tissue inflammation and destruction The low-grade inflammation and sensitivity of central nervous system progress to be the factor of chronic pain in OA In particular the definition of OA now needs to be renewed and considered as multifactor joint disorder that mainly occurs due to metabolic and inflammatory alteration that causes damage of the joints Therefore therapeutic interventions suggested for the management of OA are directly influenced by the current understating of OA pathophysiology So various inflammatory cytokines increased in OA tissues such as interleukin IL-1 IL6 IL-15 IL-17 IL-18 and Tissue necrotic factor TNF It has been proven that black cumin contributes to human body by its anti-inflammatory and anti-nociceptive properties Moreover sound waves can stimulate fluid to mobilize through the body and brain and bring oxygen and essential nutrients to the tissue Similarly A low-intensity pulsed ultrasound that uses sound waves is considered effective in reduction of inflammation
As per the researchers knowledge there is limited literature available to determine the effect of turmeric and black cumin on inflammation but there is very little known about the quantum acoustic waves on inflammation so this study aims to determine the effects of quantum acoustic waves with black cumin and turmeric
As per the researchers knowledge there is limited literature available to determine the effect of turmeric and black cumin on inflammation but there is very little known about the quantum acoustic waves on inflammation so this study aims to determine the effects of quantum acoustic waves with black cumin and turmeric
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None