Ignite Creation Date:
2024-05-11 @ 8:31 AM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06401941
Status:
COMPLETED
Last Update Posted:
2024-05-07
First Post:
2024-05-02
Brief Title:
Selected Lysosomal Enzyme Activities and the Oxidant-antioxidant Balance in Hyperbaric Oxygen Condition
Sponsor:
Nicolaus Copernicus University
Organization:
Nicolaus Copernicus University
Study Overview
Official Title:
The Impact of Staying in Hyperbaric Oxygen Conditions on the Oxidant-antioxidant Balance and the Activities of Selected Lysosomal Enzymes
Status:
COMPLETED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of the research project was to investigate the effects of hyperbaric oxygen HBO treatment on the redox equilibrium in individuals with different pathological conditions Both hyperbaric oxygenation and the pathological condition are associated with redox imbalance oxidative stress however HBO is successfully used in the treatment of chronic wounds eg diabetic foot syndrome as well as in sudden and acute hearing loss eg acute acoustic trauma or idiopathic sudden sensorineural hearing loss
Detailed Description:
The study involed in sudden sensorineural hearing loss SSNHL patients individuals with difficult-to-heal skin wounds following mechanical injuries and diabetic foot patients HBO therapy which involved inhalation of 100 oxygen at a pressure of 25 atm consisted of 14-30 sessions depending on the clinical case The study material was venous blood drawn three times before and after the first session and after the last HBO procedure The following variables were evaluated the concentrations of thiobarbituric acid reactive substances TBARS malondialdehyde MDA and conjugated dienes CD in plasma and erythrocytes the activities of catalase CAT superoxide dismutase SOD and glutathione peroxidase GPx in erythrocytes as well as blood counts
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None