Ignite Creation Date:
2024-05-11 @ 8:31 AM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06409624
Status:
RECRUITING
Last Update Posted:
2024-07-08
First Post:
2024-05-07
Brief Title:
Association Between Biomarkers and eGFR Decline in Pulmonary Hypertension
Sponsor:
University of Giessen
Organization:
University of Giessen
Study Overview
Official Title:
Association Between Biomarkers and Decline in Estimated Glomerular Filtration Rate in Patients With Pulmonary Hypertension
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objective of this study is to examine the association between urinary and plasma biomarkers and the change of estimated glomerular filtration rate eGFR in patients with pulmonary hypertension PH as a tool to identify patients at high risk for short-term eGFR decline
Detailed Description:
PH is a severe progressive disease associated with right ventricular dysfunction right-sided heart failure HF and death Chronic kidney disease CKD is approximately 35 in patients with PH and its presence is associated with an enhanced risk for adverse outcomes with the risk increasing incrementally with declining kidney function Poor right ventricular function may increase venous congestion alter ventricular interdependence decrease effective cardiac output and activate the renin-angiotensin- aldosterone system thereby aggravating kidney disease To date biomarkers for assessment of CKD progression in PH are lacking The objective of this study is to examine the association between urinary and plasma biomarkers and the change of eGFR in patients with PH aiming to identify those at high risk for short-term eGFR decline
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None