Ignite Creation Date:
2024-05-11 @ 8:31 AM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06400901
Status:
RECRUITING
Last Update Posted:
2024-05-13
First Post:
2024-04-16
Brief Title:
Analysis of Deep Brain Nuclei LFP and Cortical EEG Signals During the Recovery From General Anesthesia
Sponsor:
Ruijin Hospital
Organization:
Ruijin Hospital
Study Overview
Official Title:
Electrophysiology Based Brain Network Study on Deep Brain Nuclei LFP and Cortical EEG During the Recovery From General Anesthesia
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The correlations of deep brain nuclei firing and cerebral cortex activity during recovery from general anesthesia is unclear In this study the local field potential LFP from the deep brain nuclei and the scalp electroencephalogram EEG of the frontal cortex were recorded from patients undergoing deep brain stimulation DBS surgery during the recovery from general anesthesia in order to explore the changes and relevance of deep brain nuclei firing and cortex activity during the recovery of consciousness from general anesthesia
Detailed Description:
The recovery of consciousness during the emergence from general anesthesia is an important part of general anesthesia Previous studies have found that the recovery of consciousness is not a passive process of drug metabolism but involves the activation of functional neural networks in the brain However the temporal-spatial dynamics of different brain regions including deep brain nuclei and the cortex during recovery from general anesthesia have not been elucidated
At present thanks to the perceptible function of the new generation of deep brain stimulation DBS equipment the local field potential LFP of deep brain nuclei can be recorded in real time during the patients recovery from general anesthesia after DBS surgery This study will simultaneously record the electrophysiological signals of the patients deep brain nuclei LFP and cortical EEG signals and analyze the differences and correlations between the deep brain nuclei LFP and the cortical EEG characteristics during recovery from general anesthesia This provides evidence for understanding how subcortical deep brain nuclei are involved in the recovery of general anesthesia and provides clues for solving the mystery of consciousness
At present thanks to the perceptible function of the new generation of deep brain stimulation DBS equipment the local field potential LFP of deep brain nuclei can be recorded in real time during the patients recovery from general anesthesia after DBS surgery This study will simultaneously record the electrophysiological signals of the patients deep brain nuclei LFP and cortical EEG signals and analyze the differences and correlations between the deep brain nuclei LFP and the cortical EEG characteristics during recovery from general anesthesia This provides evidence for understanding how subcortical deep brain nuclei are involved in the recovery of general anesthesia and provides clues for solving the mystery of consciousness
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None