Ignite Creation Date:
2024-05-11 @ 8:31 AM
Last Modification Date:
2024-10-26 @ 3:28 PM
Study NCT ID:
NCT06402214
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-07
First Post:
2024-04-19
Brief Title:
The Lombard Effect in Patients Affected by Adductor Laryngeal Dystonia
Sponsor:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Organization:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study Overview
Official Title:
The Lombard Effect in Patients Affected by Adductor Laryngeal Dystonia a Pilot Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
LoQVAdSD
Brief Summary:
Adductory spasmodic dysphonia AdSD is a rare condition characterised by irregular and uncontrolled voice interruptions most commonly affecting women around the age of 45 The diagnosis is clinical and usually requires evaluation by several specialists The exact cause is not known but a disturbance of the motor system is hypothesised probably related to various causes such as loss of cortical inhibition or problems with sensory input
Neuroimaging studies have shown hyperactivity in various brain regions during speech production in patients with AdSD but it is still unclear whether this hyperactivity is due to a malfunction of auditory and somatosensory feedback or an impairment of motor programming
Recent research indicates that patients with AdSD show excessive muscle activation during phonation probably due to abnormal processing of auditory feedback This suggests that intervention in the auditory system may offer new treatment opportunities
The proposed study aims to describe the acoustic auditory-perceptual and subjective voice and speech changes in AdSD subjects during the Quick-Lombard Test LT a test that assesses vocal response under noisy conditions
Neuroimaging studies have shown hyperactivity in various brain regions during speech production in patients with AdSD but it is still unclear whether this hyperactivity is due to a malfunction of auditory and somatosensory feedback or an impairment of motor programming
Recent research indicates that patients with AdSD show excessive muscle activation during phonation probably due to abnormal processing of auditory feedback This suggests that intervention in the auditory system may offer new treatment opportunities
The proposed study aims to describe the acoustic auditory-perceptual and subjective voice and speech changes in AdSD subjects during the Quick-Lombard Test LT a test that assesses vocal response under noisy conditions
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None