Ignite Creation Date:
2024-05-19 @ 5:34 PM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06416566
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-16
First Post:
2024-05-10
Brief Title:
Low-Dose Enoxaparin in Psoriasis
Sponsor:
Zagazig University
Organization:
Zagazig University
Study Overview
Official Title:
The Efficacy of Low-Dose Enoxaparin in Psoriasis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Rationale
Psoriasis is a chronic immune-mediated inflammatory skin disorder where T cells play a fundamental role in its pathogenesis
Low molecular weight heparin has been reported to exert immunomodulatory effect at small doses through inhibition of T cells heparinase enzyme
Low molecular weight heparin may have promising results for treatment of psoriasis
Research question
Can low molecular weight heparin be used safely for treatment of psoriasis with good outcome
Is enoxaparin inhibitory effect on T cell heparinase enzyme responsible for its beneficial effect
Hypothesis
Low molecular weight heparin can achieve good results when used at small doses for treatment of psoriasis
Heparin can exert immunomodulatory effect in psoriasis through inhibition of T cell heparinase enzyme
AIM OF WORK
-The aim of this work is to assess the possible clinical efficacy and safety of low-dose enoxaparin in the treatment of psoriasis and to detect if inhibition of heparinase enzyme might account for its beneficial therapeutic effect
Objectives
To evaluate safety and efficacy of low molecular weight heparin at small dose for treatment of psoriasis
Contribute to the ongoing efforts to optimize psoriasis management and improve the lives of individuals affected by this chronic condition
Psoriasis is a chronic immune-mediated inflammatory skin disorder where T cells play a fundamental role in its pathogenesis
Low molecular weight heparin has been reported to exert immunomodulatory effect at small doses through inhibition of T cells heparinase enzyme
Low molecular weight heparin may have promising results for treatment of psoriasis
Research question
Can low molecular weight heparin be used safely for treatment of psoriasis with good outcome
Is enoxaparin inhibitory effect on T cell heparinase enzyme responsible for its beneficial effect
Hypothesis
Low molecular weight heparin can achieve good results when used at small doses for treatment of psoriasis
Heparin can exert immunomodulatory effect in psoriasis through inhibition of T cell heparinase enzyme
AIM OF WORK
-The aim of this work is to assess the possible clinical efficacy and safety of low-dose enoxaparin in the treatment of psoriasis and to detect if inhibition of heparinase enzyme might account for its beneficial therapeutic effect
Objectives
To evaluate safety and efficacy of low molecular weight heparin at small dose for treatment of psoriasis
Contribute to the ongoing efforts to optimize psoriasis management and improve the lives of individuals affected by this chronic condition
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None