Ignite Creation Date:
2024-05-19 @ 5:34 PM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06412315
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-14
First Post:
2024-03-01
Brief Title:
7T Amygdala and Citalopram Study
Sponsor:
University of Oxford
Organization:
University of Oxford
Study Overview
Official Title:
The Effects of Citalopram on the Brains Response to Faces
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
7TAC
Brief Summary:
The goal of this study is to investigate how a common antidepressant citalopram which increases the levels of the chemical messenger serotonin affects how a key area of the brain involved in depression the amygdala responds to emotional information
Healthy participants will undergo medical and psychiatric health screening after which they will be assigned to receive either a single dose of citalopram 20mg or placebo and undergo brain scanning 7T fMRI whilst viewing emotional faces Since the scan uses high field strength the investigators will be able to see effects of citalopram on different subfields within the amygdala which will help to understand how citalopram might be working
Healthy participants will undergo medical and psychiatric health screening after which they will be assigned to receive either a single dose of citalopram 20mg or placebo and undergo brain scanning 7T fMRI whilst viewing emotional faces Since the scan uses high field strength the investigators will be able to see effects of citalopram on different subfields within the amygdala which will help to understand how citalopram might be working
Detailed Description:
Antidepressants typically decrease amygdala response to negative stimuli while enhancing response to positive stimuli but it is unclear at a mechanistic level how increasing serotonin would have this opposing effect One hypothesis is that although positive and negative cues activate the same area at a global level more detailed characterisation may reveal key differences in processing in terms of localisation or response function Until now due to methodological restriction the amygdala has been mostly studied as a single structure It is however known that it consists of a number of subfields which are likely to play distinct roles in emotional processing In this study the investigators will make use of 7T fMRI scanning to study the effects of a single dose 20 mg of citalopram selective serotonin reuptake inhibitor SSRI on these subfields during emotional face processing allowing greater precision to identify underlying neural mechanisms underpinning psychological effects
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None