Ignite Creation Date:
2024-05-19 @ 5:34 PM
Last Modification Date:
2024-10-26 @ 3:29 PM
Study NCT ID:
NCT06413576
Status:
COMPLETED
Last Update Posted:
2024-05-14
First Post:
2024-04-06
Brief Title:
Homocysteine in Critically Ill Preeclampsia
Sponsor:
Ain Shams University
Organization:
Ain Shams University
Study Overview
Official Title:
The Clinical Utility of Homocysteine in Critically Ill Preeclampsia Patients
Status:
COMPLETED
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Preeclampsia is a disorder characterized by the new onset of hypertension and proteinuria typically presenting after 20 weeks of gestation Elevated circulating homocysteine is a risk factor for endothelial dysfunction and vascular diseases such as atherosclerosis and occlusive disorders Our study is to investigate the association between elevated blood homocysteine levels and complications in pregnant women in order to conclude the clinical utility of homocysteine as a marker of severity in the cases of pre-eclampsia
Detailed Description:
Hypertensive disorders of pregnancy are an important cause of morbidity and mortality among mothers and infants Preeclampsia is a pregnancy-related hypertensive disorder occurring usually after 20 weeks of gestation It is associated with fetal growth restriction low birth weight preterm birth respiratory distress syndrome and admission to a neonatal intensive care unit According to a systemic review and meta-analysis published in 2013 preeclampsia has a noticeable relationship with an increased risk of developing hypertension ischemic heart disease and cerebrovascular accident in later life
There is already abundant evidence indicating that elevated serum homocysteine levels may be related to the risk of coronary cerebral and peripheral arterial diseases Elevated circulating homocysteine is a risk factor of endothelial dysfunction and vascular diseases such as atherosclerosis and occlusive disorders Normally homocysteine levels decline throughout pregnancy and since the vascular alterations brought on by homocysteine are comparable to those brought on by hypertensive disorders of pregnancy it can be assumed that high levels of homocysteine are linked to the hypertensive disorder spectrum Homocysteine has been shown to produce oxidative stress and endothelial dysfunction endothelial cell injury and thrombus formation and thereby producing pre-eclampsia
Estimation of homocysteine may help to predict and prevent pre-eclampsia and eclampsia thus reducing the undesired outcome of pregnancy
Among various studies there is a lack of consistency in the reported results that support the link between maternal homocysteine concentrations assessed throughout each of the three trimesters of pregnancy and difficulties caused by the placenta
our study investigate the relation between the level of homocysteine and severity of preeclampsia
There is already abundant evidence indicating that elevated serum homocysteine levels may be related to the risk of coronary cerebral and peripheral arterial diseases Elevated circulating homocysteine is a risk factor of endothelial dysfunction and vascular diseases such as atherosclerosis and occlusive disorders Normally homocysteine levels decline throughout pregnancy and since the vascular alterations brought on by homocysteine are comparable to those brought on by hypertensive disorders of pregnancy it can be assumed that high levels of homocysteine are linked to the hypertensive disorder spectrum Homocysteine has been shown to produce oxidative stress and endothelial dysfunction endothelial cell injury and thrombus formation and thereby producing pre-eclampsia
Estimation of homocysteine may help to predict and prevent pre-eclampsia and eclampsia thus reducing the undesired outcome of pregnancy
Among various studies there is a lack of consistency in the reported results that support the link between maternal homocysteine concentrations assessed throughout each of the three trimesters of pregnancy and difficulties caused by the placenta
our study investigate the relation between the level of homocysteine and severity of preeclampsia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None