Ignite Creation Date:
2024-06-16 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06426303
Status:
RECRUITING
Last Update Posted:
2024-05-23
First Post:
2024-04-19
Brief Title:
Sex Differences in Trauma Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
Sponsor:
Milky Kohno
Organization:
Oregon Health and Science University
Study Overview
Official Title:
Sex Differences in Trauma Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ABSTAIN
Brief Summary:
The goal of this clinical trial is to identify sex-specific biomarkers that confer greater susceptibility for Alcohol Use Disorder AUD and differentiate how treatment response varies by sex in people with Alcohol Use Disorder
The main questions it aims to answer are
How does trauma affect emotion regulation inflammation and limbic function and what are the sex-dependent effects of NTX Naltrexone on these aspects
What is the mechanism of Naltrexone NTX and how does it potentially moderate reductions in alcohol use through changes in or interactions between emotion regulation inflammation or limbic system function
Participants will
Be consented and will undergo comprehensive screening for eligibility criteria
Complete behavioral assessments and neuropsychological assessments as well as neurocognitive assessments and neuroimaging measures
Provide urine samples for a urine drug screen UDS and urine pregnancy test for women and have blood and a cheek swab collected and stored in the repository
Take a study drug once daily for 12 weeks and track drug usage and effects in a study journal
Undergo weekly assessment calls and bi-weekly medical follow-up safety exams
Researchers will compare naltrexone to placebo in AUD to see if naltrexone is effective in reducing alcohol cravings and promoting abstinence
Researchers will also compare baseline measures between AUD and Healthy Controls
The main questions it aims to answer are
How does trauma affect emotion regulation inflammation and limbic function and what are the sex-dependent effects of NTX Naltrexone on these aspects
What is the mechanism of Naltrexone NTX and how does it potentially moderate reductions in alcohol use through changes in or interactions between emotion regulation inflammation or limbic system function
Participants will
Be consented and will undergo comprehensive screening for eligibility criteria
Complete behavioral assessments and neuropsychological assessments as well as neurocognitive assessments and neuroimaging measures
Provide urine samples for a urine drug screen UDS and urine pregnancy test for women and have blood and a cheek swab collected and stored in the repository
Take a study drug once daily for 12 weeks and track drug usage and effects in a study journal
Undergo weekly assessment calls and bi-weekly medical follow-up safety exams
Researchers will compare naltrexone to placebo in AUD to see if naltrexone is effective in reducing alcohol cravings and promoting abstinence
Researchers will also compare baseline measures between AUD and Healthy Controls
Detailed Description:
A twelve-week randomized placebo-controlled trial of naltrexone NTX will be conducted in one hundred people with alcohol use disorder AUD fifty of which will be women Fifty healthy participants will serve as controls for baseline measures We will use validated measures to comprehensively assess trauma exposure including military sexual trauma MST physical or sexual assault combat exposure intimate partner violence and other traumatic events Emotion regulation will be assessed with the Cognitive Emotion Regulation questionnaire and Difficulty in Emotion Regulation scale Functional magnetic resonance imaging at rest and during an emotion regulation task will assess limbic system connectivity and reactivity Inflammation will be indexed with a multiplex panel assay of peripheral inflammatory markers Days of alcohol use and average weekly standard drinks will be assessed at each time-point
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
True
Is an FDA AA801 Violation?:
None