Ignite Creation Date:
2024-06-16 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06420310
Status:
RECRUITING
Last Update Posted:
2024-05-20
First Post:
2024-05-14
Brief Title:
Pesticides and Parkinsons Disease
Sponsor:
Hospital Universitario de Burgos
Organization:
Hospital Universitario de Burgos
Study Overview
Official Title:
Prevalence of Preclinical and Prodromal Parkinsons Disease in Subjects Exposed to Pesticides
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Pest-PD
Brief Summary:
The aim of this project is to study whether people exposed to pesticides have a higher risk of developing PD We will perform an epidemiological study determining the presence of pesticides in urine and comparing signs traditionally associated with PD in early forms
Detailed Description:
Within different risk factors pesticide exposure increases the risk of developing Parkinsons disease PD through epigenetic mechanisms by modifying the expression of genes related to PD and secondary mitochondrial dysfunctionWe will conduct a cross-sectional prevalence study with cases exposed to pesticides and controls not exposed to pesticides randomly selecting 130 individuals in each group Pesticide exposure will be determined through questionnairesWe will study the prevalence of preclinical and prodromal PD based on pesticide exposure stratified by age and gender in the exposed and non-exposed groups Preclinical and prodromal PD will be assessed using biological biomarkers and prodromal PD signs Multivariate analyses will be employed to determine the risk of presenting early PD adjusting for different clinical covariates The results of this study will allow us to understand the early mechanisms associated with neurodegeneration and pesticides exposure
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None