Ignite Creation Date:
2024-06-16 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06429891
Status:
RECRUITING
Last Update Posted:
2024-05-28
First Post:
2024-05-21
Brief Title:
Research on Early Diagnosis and Clinical Transformation of Nuclide Probe Based on Bioorthogonal-gastric Cancer Mucin Target Visualization
Sponsor:
Hua Zhu
Organization:
Peking University Cancer Hospital Institute
Study Overview
Official Title:
Research on Early Diagnosis and Clinical Transformation of Nuclide Probe Based on Bioorthogonal-gastric Cancer Mucin Target Visualization
Status:
RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The symptoms of early gastric cancer are extremely insidious and most patients are identified as advanced at the time of initial diagnosis Starting from the clinical needs this project selects solid tumors and pathogenic glycoprotein synthesis of key glycopeptide antigen determinant mucin MUC family of multiple molecules as the research object Based on the digestive system tumor research cohort established in the early stage this project intends to verify the tumor microenvironment characteristics of the MUC family and gastric cancer treatment resistance through immunohistochemistry COSMC gene sequencing and other technologies and screen key MUC family proteins Based on the discovery of differential recognition of COSMC deficient cells by antibodies MUC1-targeted specific monoclonal antibody was developed Further development of spatial mucinomics based on laser ablation inductively coupled plasma mass spectrometry LA-IPC-MS and spatial metabolome based on desorption electrospray mass spectrometry DESI-MS to analyze the structure and immunosuppressive mechanism of key gastric cancer glycoprotein MUC After obtaining key targeted antibodies with the help of biological orthogonal and click chemistry technology the original clinical translational research based on mucin targeting was carried out and a high-affinity nuclide conjugate drug RDC with triple binding of gastric cancer mucin was constructed and clinical translational research was carried out which provided new ideas for the accurate diagnosis and treatment of gastric cancer in the early stage
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None