Ignite Creation Date:
2024-06-16 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06427460
Status:
RECRUITING
Last Update Posted:
2024-05-23
First Post:
2024-05-19
Brief Title:
Central-boost Ablative Radiation Therapy for Solid Tumors CBART
Sponsor:
Changhai Hospital
Organization:
Changhai Hospital
Study Overview
Official Title:
Central-boost Ablative Radiation Therapy for Large Tumors or Tumors Adjacent to Organs at Risk
Status:
RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In the case of large tumors or tumors closely adjacent to organs at risk ablative doses offered by stereotactic body radiation therapy SBRT could not be delivered Therefore a technique that could provide high radiation doses to tumors without increasing of risks of severe adverse effects is required
Detailed Description:
Regarding the advanced stage tumor especially tumors with large volumes or closely adjacent to organs at risk patients are not candidates for surgical resection Therefore raduitherapy may be the optimal local therapy to ameliorate symptoms and be combined with systemic therapy including chemotherapy targeted therapy or immunotherapy However for those tumors ablative doses could not be given due to large volumes and abutting to organs at risk
In order to solve the problem spatially fractionated radiation therapy SFRT is used In details it was performed based on grid or lattice which creates several cylindrical high-radiation-dose areas in tumors Nevertheless the ablative dose areas are limited albeit with SFRT which may not greatly improve tumor local Hence we create an inner and complete inner gross tumor volume that would be delivered ablative radiation doses which is named as central-boost ablative radiation therapy CBART We aim to investigate the efficacy and safety of CBART in large tumors or tumors adjacent to organs at risk
In order to solve the problem spatially fractionated radiation therapy SFRT is used In details it was performed based on grid or lattice which creates several cylindrical high-radiation-dose areas in tumors Nevertheless the ablative dose areas are limited albeit with SFRT which may not greatly improve tumor local Hence we create an inner and complete inner gross tumor volume that would be delivered ablative radiation doses which is named as central-boost ablative radiation therapy CBART We aim to investigate the efficacy and safety of CBART in large tumors or tumors adjacent to organs at risk
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None