Ignite Creation Date:
2024-06-16 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06428890
Status:
COMPLETED
Last Update Posted:
2024-05-24
First Post:
2024-05-15
Brief Title:
Effect of 7 Days of Grape Seed Extract Supplementation on Cold Pressor Test and Muscle Metaboreflex in Individuals With Elevated and Stage 1 Hypertension
Sponsor:
California Baptist University
Organization:
California Baptist University
Study Overview
Official Title:
Effect of 7 Days of Grape Seed Extract Supplementation on Cold Pressor Test and Muscle Metaboreflex in Individuals With Elevated and Stage 1 Hypertension
Status:
COMPLETED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aimed to assess the effect of the supplementation with grape seed extract GSE on blood pressure during static handgrip exercise and muscle metaboreflex in individuals with elevated and state 1 hypertension
Detailed Description:
Muscle metatoreflex MMR has been known to play an important role in adjusting hemodynamic responses during exercise The reflex increases sympathetic activity to heart and blood vessels to increase blood supply to contracting skeletal muscles On the other hand studies demonstrated that abnormal cardiovascular responses occurred by the overactive MMR in pathological conditions such as hypertension diabetes and congestive heart failure Excessive blood pressure BP responses to exercise induce cardiovascular events such as stroke heart attack and coronary artery disease Previously a study found that dietary supplementation with grape seed extract GSE reduced BP response to dynamic exercise in individuals with elevated and stage 1 hypertension ES1H and associated with peripheral vasodilation However mechanisms underlying this phenomenon are not clear Purpose therefore the purpose of this study is to investigate whether chronic dietary supplementation with GSE can decrease BP responses to exercise and this observation is associated with reduced MMR Methods 12 ES1H males were studied Changes in cardiac output Q mean arterial pressure MAP and total peripheral resistance TPR were compared between the GSE and placebo supplementations during static handgrip exercise SHE and post exercise muscular ischemia PEMI Participants completed 3 min of SHE at 40 of MVC followed by 2 min of PEMI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None