Ignite Creation Date:
2024-06-16 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06427902
Status:
COMPLETED
Last Update Posted:
2024-05-24
First Post:
2024-05-16
Brief Title:
Inflammatory Biomarkers in Saliva at Depression
Sponsor:
Medipol University
Organization:
Medipol University
Study Overview
Official Title:
Salivary Biomarkers of Gingival Inflammation Are Associated With Depression
Status:
COMPLETED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this observational study is to evaluate the inflammatory saliva biomarkers in depression and gingivitis
The main question will be Will there be an increase at salivary biomarkers with depression patients and is it associated with gingivitis
The main question will be Will there be an increase at salivary biomarkers with depression patients and is it associated with gingivitis
Detailed Description:
Background The neuroimmune regulation disorder in depression patients causes the progression of inflammatory periodontal disease The present study was to evaluate the periodontal health status and the levels of Triggering receptor expressed on myeloid cells 1 TREM-1 peptidoglycan recognition protein 1 PGLYRP1 and interleukin-1 beta IL-1β in individuals diagnosed with depression and to compare these findings with those of systemically healthy individuals
Methods Forty-two depression patients were classified in two groups depression with gingivitis DG and depression with periodontally healthy DPH patients Additionally 23 systemically and periodontally healthy SPH individuals were enrolled to the study Periodontal parameters were recorded Saliva samples were collected and salivary levels of TREM-1 PGLYRP1 IL-1β were measured using Enzyme-linked Immunosorbent Assay ELISA kits
depression regardless of periodontal status
Methods Forty-two depression patients were classified in two groups depression with gingivitis DG and depression with periodontally healthy DPH patients Additionally 23 systemically and periodontally healthy SPH individuals were enrolled to the study Periodontal parameters were recorded Saliva samples were collected and salivary levels of TREM-1 PGLYRP1 IL-1β were measured using Enzyme-linked Immunosorbent Assay ELISA kits
depression regardless of periodontal status
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None