Ignite Creation Date:
2024-06-16 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06426017
Status:
COMPLETED
Last Update Posted:
2024-05-23
First Post:
2024-05-17
Brief Title:
Impact of FTO Gene Variation on Body Composition Lipid Profile Insulin Resistance Advanced Glycation End-Products and Ghrelin Levels in Response to Hypocaloric Protein Rich-Diet
Sponsor:
Khyber Medical University Peshawar
Organization:
Khyber Medical University Peshawar
Study Overview
Official Title:
Impact of FTO Gene Variation on Body Composition Lipid Profile Insulin Resistance Advanced Glycation End-Products and Ghrelin Levels in Response to Hypocaloric Protein Rich-Diet
Status:
COMPLETED
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Obesity is a widespread disease that basically develops from unhealthy lifestyle and genetics The Fat-mass and obesity associated FTO gene affects appetite and energy intake of the body thus elevating fat mass and body weight The single nucleotide polymorphism SNP rs9939609 of the FTO gene is a common variant in different ethnic groups and its A allele is associated with increased body mass and waist circumference Hence the carriers of rs9939609 SNP are prone to weight gain if a healthy diet and lifestyle are not maintained Similarly high levels of serum cholesterol and triglycerides while low levels of high-density lipoproteins are observed in carriers of rs9939609 AA genotype For individuals having FTO rs9939609 A allele consumption of hypocaloric diets 1500 kcalday consisting of high protein foods up to 25-30 of total daily energy intake might help reduce body weight However weight loss tends to vary in individuals after consuming the same diet under similar environmental conditions so it is important to know the effect of different genotypes that might cause this variation The study aimed to genotype overweight and obese adults for FTO rs9939609 polymorphism and to determine the effect of this polymorphism on body weight BMI waist and hip circumferences lipid profile insulin sensitivity ghrelin levels inflammatory markers and advanced glycation end-products in these individuals after consumption of a hypocaloric high-protein diet for 4 weeks
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None