Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005348
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Adipose Distribution and Atherosclerosis
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To relate distribution of adipose tissue measured by a then new imaging technique Magnetic Resonance Imaging MRI to extracranial carotid atherosclerosis cardiovascular disease risk factors and to more conventional measures of fat distribution such as body mass index BMI and waisthip ratio The primary hypothesis was that patients with extracranial carotid atherosclerosis cases had more intra-abdominal fat and a higher ratio of intra-abdominal fat to total or subcutaneous fat than age-sex-race matched controls
Detailed Description:
BACKGROUND
The study was ancillary to an NIH funded population-based project the Atherosclerosis Risk in Communities Study ARIC that is ongoing in Forsyth County North Carolina
DESIGN NARRATIVE
Using MRI the investigators sought to demonstrate strong relationships between intra-abdominal fat and a number of cardiovascular disease risk factors including history of hypertension diabetes cigarette smoking family history of cardiovascular disease plasma concentrations of triglyceride high density lipoprotein HDL cholesterol HDL2 cholesterol apo A1 Apo B postprandial lipid response to a fat rich meal glucose insulin sex hormone binding globulin and total and free testosterone Certain other risk factors were less certain to show a relation to intra-abdominal fat as measured by MRI including various hemostatic factors as well as certain dietary factors such as consumption of alcohol dietary fat and cholesterol but this research afforded an opportunity to explore these relationships Finally the investigators proposed to relate intra-abdominal fat to more conventional measures of fat distribution waisthip ratio subscapular skinfold thickness etc in an attempt to identify strong correlates of intra-abdominal fat that could be more easily measured
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS recor
The study was ancillary to an NIH funded population-based project the Atherosclerosis Risk in Communities Study ARIC that is ongoing in Forsyth County North Carolina
DESIGN NARRATIVE
Using MRI the investigators sought to demonstrate strong relationships between intra-abdominal fat and a number of cardiovascular disease risk factors including history of hypertension diabetes cigarette smoking family history of cardiovascular disease plasma concentrations of triglyceride high density lipoprotein HDL cholesterol HDL2 cholesterol apo A1 Apo B postprandial lipid response to a fat rich meal glucose insulin sex hormone binding globulin and total and free testosterone Certain other risk factors were less certain to show a relation to intra-abdominal fat as measured by MRI including various hemostatic factors as well as certain dietary factors such as consumption of alcohol dietary fat and cholesterol but this research afforded an opportunity to explore these relationships Finally the investigators proposed to relate intra-abdominal fat to more conventional measures of fat distribution waisthip ratio subscapular skinfold thickness etc in an attempt to identify strong correlates of intra-abdominal fat that could be more easily measured
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS recor
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL046208 | NIH | None | httpsreporternihgovquickSearchR01HL046208 |