Ignite Creation Date:
2024-06-16 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06424015
Status:
RECRUITING
Last Update Posted:
2024-05-21
First Post:
2024-05-13
Brief Title:
Insulin and Insulin Pulses During Fasting
Sponsor:
Mayo Clinic
Organization:
Mayo Clinic
Study Overview
Official Title:
Effect of Insulin and Insulin Pulses on Fasting Glucagon Secretion and on Glucose Metabolism in Subjects Without Type 2 Diabetes
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes However little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state The proposed experiment is part of a series of experiments designed to establish how glucagon and insulin interact with their receptors to control fasting glucose in health and in prediabetes
Detailed Description:
Decreased insulin action increases glucagon concentrations In rodents insulin signaling restrains glucagon secretion It is unclear if this is the case in all subtypes of prediabetes Impaired hepatic insulin action exacerbates glucagons effects on endogenous glucose production Also insulin resistance in the β-cell impairs negative feedback inhibition of insulin secretion This leads to hyperinsulinemia in rodents and humans How these variables interact is unknown This experiment will determine how insulin variably regulates fasting glucagon and insulin secretion directly or indirectly in prediabetes
The inability of the proinsulin to insulin ratio to reliably predict β-cell integrity endoplasmic reticulum stress and β-cell function has led to the identification of novel markers of β-cell health In addition the relationship of glucagon and insulin pulses will be quantified Preliminary data shows that there is heterogeneity in these relationships even in normal fasting glucose Th experiment will also determine how islet hormone glucose crosstalk and pulse characteristics contribute to prediabetes
The inability of the proinsulin to insulin ratio to reliably predict β-cell integrity endoplasmic reticulum stress and β-cell function has led to the identification of novel markers of β-cell health In addition the relationship of glucagon and insulin pulses will be quantified Preliminary data shows that there is heterogeneity in these relationships even in normal fasting glucose Th experiment will also determine how islet hormone glucose crosstalk and pulse characteristics contribute to prediabetes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None