Ignite Creation Date:
2024-06-16 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06428539
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-29
First Post:
2024-05-21
Brief Title:
T Regulatory Cells IN LUPUS NEPHRITIS
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
T Regulatory Cells in Lupus Nephritis
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To study the role FoxP3-positive T regulatory cells in the pathogenesis of Lupus Nephritis and determine the factors associated with levels of T regs
To compare the functional capacity of T regs in LN and in normal individuals
To compare the functional capacity of T regs in LN and in normal individuals
Detailed Description:
Lupus Nephritis LN encompasses a group of glomerulonephrites that occur in association with systemic lupus erythematosus SLE The mainstream theory that it is an immune disease resulting from loss of immune tolerance against body cells The regulatory T cells T regs are a subpopulation of immune cells that maintain tolerance to self-antigens and suppress autoimmune diseases The main marker of Tregs is FoxP3 forkhead box protein 3 positivity Moreover It has been suggested that functional capacity of Tregs is also compromised in autoimmune diseases Studying the role of T regs in LN is a promising field that can help tailor current immune therapy and develop new treatment strategies
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None