Ignite Creation Date:
2024-06-16 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06437925
Status:
COMPLETED
Last Update Posted:
2024-05-31
First Post:
2024-05-22
Brief Title:
Effects of Probiotic Ayran on Gingivitis
Sponsor:
Cukurova University
Organization:
Cukurova University
Study Overview
Official Title:
Effects of the Use of Probiotics Ayran on Gingival Inflammation An Experimental Gingivitis Study
Status:
COMPLETED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Objectives This study investigates the effects of daily consumption of probiotic ayran drink on gingival inflammation and the development of experimental gingivitis
Methods A total of 54volunteer students were included in the present randomized double-blind placebo-controlled trialThe participants were divided randomly into two groups The Control group consisted of 27 participants who consumed placebo ayran while the 27 participants of the Test group consumed probiotic ayran containing Lactobacillus acidophilus and Bifidobacterium bifidum for 42 days twice a dayAfter 42 days mechanical plaque control was interrupted for 5 days The clinical parameters of gingivitis Plaque index PI gingival index GI probing bleeding BOP probing depth PPD were recorded at baseline day 42 beginning of experimental gingivitis and day 47 the end of experimental gingivitis At the same time points gingival crevicular fluid had been collected for analysis of matrix metalloproteinase - 8 MMP-8
Methods A total of 54volunteer students were included in the present randomized double-blind placebo-controlled trialThe participants were divided randomly into two groups The Control group consisted of 27 participants who consumed placebo ayran while the 27 participants of the Test group consumed probiotic ayran containing Lactobacillus acidophilus and Bifidobacterium bifidum for 42 days twice a dayAfter 42 days mechanical plaque control was interrupted for 5 days The clinical parameters of gingivitis Plaque index PI gingival index GI probing bleeding BOP probing depth PPD were recorded at baseline day 42 beginning of experimental gingivitis and day 47 the end of experimental gingivitis At the same time points gingival crevicular fluid had been collected for analysis of matrix metalloproteinase - 8 MMP-8
Detailed Description:
The most used and studied probiotics in the periodontal literature are lactobacillus and bifidobacterium The current study aims to observe the effects of daily ayran consumption containing a probiotic combination of Lactobacillus acidophilus and Bifidobacterium bifidum on plaque development and gingival inflammation in an experimental gingivitis model of healthy individuals The null hypothesis of this study using of probiotics has no additional benefit for periodontal health
This study evaluates the effects of daily consumption of ayran containing a probiotic combination of Lactobacillus Acidophilus and Bifidobacterium Bifidum on plaque development and gingival status in healthy individuals with experimental gingivitis
This study evaluates the effects of daily consumption of ayran containing a probiotic combination of Lactobacillus Acidophilus and Bifidobacterium Bifidum on plaque development and gingival status in healthy individuals with experimental gingivitis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None