Ignite Creation Date:
2024-06-16 @ 11:49 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06436586
Status:
COMPLETED
Last Update Posted:
2024-05-31
First Post:
2024-05-24
Brief Title:
Impact of HLA Evolutionary Divergence and HLA Donor-recipient Molecular Mismatches on Kidney Allograft Rejection
Sponsor:
Paris Translational Research Center for Organ Transplantation
Organization:
Paris Translational Research Center for Organ Transplantation
Study Overview
Official Title:
Impact of HLA Evolutionary Divergence and HLA Donor-recipient Molecular Mismatches on Kidney Allograft Rejection a Population-based Study
Status:
COMPLETED
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The Human Leucocyte Antigen HLA system is pivotal in kidney transplant rejection In-silico methods such as HLA eplet mismatches and PIRCHE-II scores have emerged to refine HLA immunogenicity assessment and stratify patients for immunological risk However large-scale studies in unselected large kidney transplant cohorts are lacking to support their broader clinical applicability Additionally recent studies on HLA evolutionary divergence HED quantifying HLA polymorphism highlight its potential impact on rejection Yet the association of HED with kidney allograft rejection or de novo DSA occurrence remains unexplored in kidney transplantation
The complexity introduced by diverse in-silico methods for assessing HLA immunogenicity necessitates further research to comprehensively understand their role in relation to kidney allograft rejection
This project thus aims to investigate the association between various aspects of HLA immunogenicity including HLA molecular mismatches and HLA evolutionary divergence along with standard immunological and clinical parameters assessed at the time of transplantation with the occurrence of antibody-mediated rejection and de novo DSA formation post-transplant in a large comprehensively annotated kidney transplant cohort
The complexity introduced by diverse in-silico methods for assessing HLA immunogenicity necessitates further research to comprehensively understand their role in relation to kidney allograft rejection
This project thus aims to investigate the association between various aspects of HLA immunogenicity including HLA molecular mismatches and HLA evolutionary divergence along with standard immunological and clinical parameters assessed at the time of transplantation with the occurrence of antibody-mediated rejection and de novo DSA formation post-transplant in a large comprehensively annotated kidney transplant cohort
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None