Ignite Creation Date:
2024-06-16 @ 11:49 AM
Last Modification Date:
2024-10-26 @ 3:30 PM
Study NCT ID:
NCT06435741
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-05-30
First Post:
2024-05-26
Brief Title:
Molecular Imaging of Gastric Cancer Metastatic Lymph Nodes with 99mTc-3PRGD2 Probe
Sponsor:
Peking University Cancer Hospital Institute
Organization:
Peking University Cancer Hospital Institute
Study Overview
Official Title:
Lymph Node Dissection of Gastric Cancer Based on Molecular Imaging of Metastatic Lymph Nodes of Gastric Cancer with 99mTc-3PRGD2 Probes
Status:
NOT_YET_RECRUITING
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Surgical lymph node dissection is the key to advanced gastric cancer In recent years after the overall implementation of standard D2 dissection lymph node dissection for gastric cancer began to explore the direction of D1 again Current clinical studies of gastric cancer lymph node dissection based on intraoperative fluorescence navigation show that non-tumor specific lymph node fluorescence navigation surgery can only increase the total number of lymph nodes detected and ensure the completion of the dissection but not the accuracy The sensitivity and specificity of the tracer metastatic lymph nodes are 563 410728 respectively Specificity 461 26695785 Tumor specific tracing of positive lymph nodes is the key to achieve accurate lymph node dissection for gastric cancer Although tumor specific tracers are developing rapidly and related clinical studies are gradually being carried out there are few reports on specific clinical studies on lymph node metastasis suggesting that lymph node tracing is still a difficult problem Previous basic studies have suggested that integrins play an important molecular biological role in the process of tumor lymph node metastasis In the early stage 99mTc3PRGD2 SPECT-CT showed good lymph node imaging effect in lung cancer and breast cancer and 99mTc-oncoFAPI PET-CT also showed good lymph node imaging effect in gastric cancer Therefore this study aims to explore the application prospect of 99mTc3PRGD2 and other probes in molecular imaging of gastric cancer metastatic lymph nodes and guidance of lymph node dissection and tracer so as to accumulate preliminary clinical data for exploring corresponding fluorescent probes for intraoperative tracer of gastric cancer lymph nodes
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None