Ignite Creation Date:
2024-06-16 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06447467
Status:
RECRUITING
Last Update Posted:
2024-06-20
First Post:
2024-06-03
Brief Title:
Short Term Outcome of Acute Heart Failure in Diabetic and Non Diabetic Patients
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Short Term Outcome of Acute Heart Failure in Diabetic and Non Diabetic Patients
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Around 26 million people suffer from heart failure HF globally and the prevalence is increasing with an increasing longevity prevalence of risk factors and improved survival in patients with cardiovascular diseases In Egypt HF is the primary cause of hospitalization among patients aged 65 years Hospitalization for HF is associated with a high mortality and rate of re-hospitalization Around 75 patients with HF have 1 comorbidity and these comorbidities make overall clinical outcomes worse In a recent meta-analysis patients with diabetes mellitus DM were suggested to have a two-fold increase in the risk of HF DM is present in 35 patients hospitalized with acute HF Multiple factors such as ischemia hypertension and extracellular fluid volume expansion are involved in the pathogenesis of HF in DM
Detailed Description:
The prevalence of both heart failure HF and diabetes has increased over the last decades and is expected to do so in the upcoming decades Therefore the presence of diabetes in patients with HF is also likely to increase and this is anticipated to become a major health concern The actual prevalence of diabetes in patients with acute HF in different registries has varied but may be as high as 45 Because the structure and function of the heart is directly influenced by the presence of diabetes diabetes is to be considered to represent more than just a co morbid condition in HF
Diabetes has been shown to be an independent risk factor for the development of HF Moreover this risk has been shown to be age and sex dependent Compared with patients without diabetes the presence of diabetes doubles the risk of HF in men and the risk of developing HF in women may be as much as four times higher These associations may even be stronger in younger patients Furthermore the presence of diabetes has been associated with a longer duration of hospitalization and higher rates of rehospitalization among patients with acute HF Importantly in patients with HF it has been established that the presence of diabetes is not only associated with an increased cardiovascular morbidity but also with an increased mortality
Diabetes has been shown to be an independent risk factor for the development of HF Moreover this risk has been shown to be age and sex dependent Compared with patients without diabetes the presence of diabetes doubles the risk of HF in men and the risk of developing HF in women may be as much as four times higher These associations may even be stronger in younger patients Furthermore the presence of diabetes has been associated with a longer duration of hospitalization and higher rates of rehospitalization among patients with acute HF Importantly in patients with HF it has been established that the presence of diabetes is not only associated with an increased cardiovascular morbidity but also with an increased mortality
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None