Ignite Creation Date:
2024-06-16 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06449794
Status:
RECRUITING
Last Update Posted:
2024-06-11
First Post:
2024-06-04
Brief Title:
Neuropsycatric Disorders Among Children With Systemic Lupus Erythematosus in Sohag University Hospital
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Neuropsycatric Disorders Among Children With Systemic Lupus Erythematosus in Sohag University Hospital
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Systemic lupus erythematosus SLE is a chronic autoimmune disease involving multiple organs characterized by the production of autoantibodies and the development of tissue injury The etiology of SLE is partially known involving multiple genetic and environmental factors As many as 50 of patients with SLE have neurological involvement during the course of their disease Approximately 40 of neuropsychiatric SLE NPSLE cases are a consequence of the disease itself other causes of NPSLE are infections metabolic disorders and side effects of drugs The American College of Rheumatology identified 19 neuropsychiatric syndromes in SLE patients that can be divided into central and peripheral nervous system manifestations Although this classification includes syndromes with no clear pathophysiological mechanism and is not specific for neuropsychiatric events caused exclusively by SLE it helps the physician to recognize any neurological involvement The most common clinical manifestations of juvenile neuropsychiatric SLE NPSLE are headache cognitive dysfunction mood disturbances and seizures The pathophysiology of juvenile NPSLE is not yet fully known but immunological and inflammatory factors such as autoantibodies cytokine and prothrombotic states are widely described The of autoantibodies in the onset of specific clinical manifestations has also been recognized Juvenile NPSLE manifestations are often difficult to diagnose Nineteen neuropsychiatric syndromes have been identified associated with SLE can be divided into central and peripheral manifestations
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None