Ignite Creation Date:
2024-06-16 @ 11:50 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06449846
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-10
First Post:
2024-04-30
Brief Title:
Compare the Accuracy of ctDNA-MRD and MVI Result in Predicting Postoperative Recurrence of Hepatocellular Carcinoma
Sponsor:
Zhujiang Hospital
Organization:
Zhujiang Hospital
Study Overview
Official Title:
Compare the Accuracy of Circulating Tumor DNA Longitudinal Monitoring Minimal Residual Disease and Microvascular Invasion Result in Predicting Postoperative Recurrence of Hepatocellular Carcinoma
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study was to compare the accuracy of ctDNA-MRD longitudinal surveillance model and internationally accepted pathological MVI results in predicting recurrence after radical hepatectomy At the same time to explore the relationship among the two methods of predicting recurrence of hepatocellular carcinoma postoperative adjuvant therapy and postoperative recurrence this study further confirmed the effectiveness of ctDNA-MRD longitudinal monitoring model in monitoring postoperative recurrence of hepatocellular carcinoma and guiding treatment
Detailed Description:
The recurrence rate of hepatocellular carcinoma HCC after radical hepatectomy is high and there is no universally accepted adjuvant therapy to prevent recurrence of liver cancer at presentThe high-risk recurrent population can not be accurately and dynamically located The results showed that minimal residual disease MRD was the root of recurrence of HCC and the results of MRD were the important indicator of adjuvant therapy Our previous research confirmed that the circulating tumor DNA ctDNA-MRD monitoring model can accurately predict the recurrence of HCC which provides important evidence for the application of MRD in predicting the recurrence of early HCC It was also found in the retrospective analysis that the patients with ctDNA positive after radical hepatectomy were treated with targeted therapy and other comprehensive therapies while ctDNA converting to negative the tumor-free survival was significantly prolonged
Microvascular invasion MVI is a pathological concept which refers to the nests of cancer cells in the lumen of small blood vessels under the microscope the results of MVI can be obtained by pathological examination of the tumor tissue after hepatectomy MVI is common in HCC and is associated with early recurrence and decreased survival MVI is an important determinant of survival after radical hepatectomy the grade severity of MVI is generally associated with tumor stage and the rate of liver cancer disease progression which has been widely studied and recognized internationally
The aim of this study was to compare the accuracy of ctDNA-MRD longitudinal surveillance model and internationally accepted pathological MVI results in predicting recurrence after radical hepatectomy At the same time to explore the relationship among the two methods of predicting recurrence of hepatocellular carcinoma postoperative adjuvant therapy and postoperative recurrence this study further confirmed the effectiveness of ctDNA-MRD longitudinal monitoring model in monitoring postoperative recurrence of hepatocellular carcinoma and guiding treatment
Microvascular invasion MVI is a pathological concept which refers to the nests of cancer cells in the lumen of small blood vessels under the microscope the results of MVI can be obtained by pathological examination of the tumor tissue after hepatectomy MVI is common in HCC and is associated with early recurrence and decreased survival MVI is an important determinant of survival after radical hepatectomy the grade severity of MVI is generally associated with tumor stage and the rate of liver cancer disease progression which has been widely studied and recognized internationally
The aim of this study was to compare the accuracy of ctDNA-MRD longitudinal surveillance model and internationally accepted pathological MVI results in predicting recurrence after radical hepatectomy At the same time to explore the relationship among the two methods of predicting recurrence of hepatocellular carcinoma postoperative adjuvant therapy and postoperative recurrence this study further confirmed the effectiveness of ctDNA-MRD longitudinal monitoring model in monitoring postoperative recurrence of hepatocellular carcinoma and guiding treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None