Ignite Creation Date:
2024-06-16 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06445634
Status:
RECRUITING
Last Update Posted:
2024-06-06
First Post:
2024-05-31
Brief Title:
Outcome of GATT Combined With Goniosynechiolysis in Glaucoma Patients With Secondary Synechial Angle Closure
Sponsor:
Kasr El Aini Hospital
Organization:
Kasr El Aini Hospital
Study Overview
Official Title:
Outcome of Gonioscopy-Assisted Transluminal Trabeculotomy Combined With Goniosynechiolysis in Glaucoma Patients With Secondary Synechial Angle Closure A Prospective Case Series
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To evaluate the intraocular pressure reduction effect of combined gonioscopy-assisted transluminal trabeculotomy GATT with goniosynechialysis in eyes with secondary synechial angle closure glaucoma
Detailed Description:
Glaucoma is a group of diseases that present with cupping of the optic nerve head and visual-field defects It is the most common cause of irreversible blindness all over the worldAngle-closure glaucoma is a type of glaucoma characterized by narrowing or closure of the anterior chamber angle
Two major types of angle closure glaucoma are defined by the mechanism of angle closure in appositional contact the iris is pushed by a pressure difference between the posterior and anterior chambers due to relative pupillary block while in synechial contact the peripheral iris adheres to the trabecular meshwork by peripheral anterior synechiae PAS PAS can develop in various ocular conditions including ocular inflammation a post-traumatic condition after cataract surgery or with an iris bombe in a pupillary block glaucoma
Grover et al described a technique for ab-Interno circumferential trabeculotomy termed gonioscopy-assisted transluminal trabeculotomy GATT The procedure aims to create a 360 trabeculotomy from an ab-Interno approach
GATT procedure is a MIGS technique in which trabecular meshwork is circumferentially bypassed by incising it using a suture or microcatheterIn this technique aqueous humor passes through the collector channels and episcleral veins through the cleaved open diseased trabecular meshwork
Elsayed et al previously demonstrated that combining phacoemulsification with GATT in PACG yielded more favorable outcomes in terms of IOP glaucoma medications and surgical success compared to phacoemulsification aloneHowever to date no studies have looked at the outcomes of combining goniosynechialysis with GATT in secondary angle closure glaucoma In fact most studies looking at the outcomes of GATT in different types of glaucoma excluded eyes with synechial angle closure
Goniosynechialysis GSL is the process of physically separating PAS which can develop in the trabecular meshwork due to various conditions including primary and secondary cases of angle closure
So for those cases of synechial angle closure glaucoma combining GATT and GSL might aid in the IOP lowering effect required
Two major types of angle closure glaucoma are defined by the mechanism of angle closure in appositional contact the iris is pushed by a pressure difference between the posterior and anterior chambers due to relative pupillary block while in synechial contact the peripheral iris adheres to the trabecular meshwork by peripheral anterior synechiae PAS PAS can develop in various ocular conditions including ocular inflammation a post-traumatic condition after cataract surgery or with an iris bombe in a pupillary block glaucoma
Grover et al described a technique for ab-Interno circumferential trabeculotomy termed gonioscopy-assisted transluminal trabeculotomy GATT The procedure aims to create a 360 trabeculotomy from an ab-Interno approach
GATT procedure is a MIGS technique in which trabecular meshwork is circumferentially bypassed by incising it using a suture or microcatheterIn this technique aqueous humor passes through the collector channels and episcleral veins through the cleaved open diseased trabecular meshwork
Elsayed et al previously demonstrated that combining phacoemulsification with GATT in PACG yielded more favorable outcomes in terms of IOP glaucoma medications and surgical success compared to phacoemulsification aloneHowever to date no studies have looked at the outcomes of combining goniosynechialysis with GATT in secondary angle closure glaucoma In fact most studies looking at the outcomes of GATT in different types of glaucoma excluded eyes with synechial angle closure
Goniosynechialysis GSL is the process of physically separating PAS which can develop in the trabecular meshwork due to various conditions including primary and secondary cases of angle closure
So for those cases of synechial angle closure glaucoma combining GATT and GSL might aid in the IOP lowering effect required
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None