Ignite Creation Date:
2024-06-16 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06457217
Status:
RECRUITING
Last Update Posted:
2024-06-13
First Post:
2024-06-10
Brief Title:
MRSI Evaluation for Minor Stroke With Large Vessel Occlusion
Sponsor:
Shanghai 6th Peoples Hospital
Organization:
Shanghai 6th Peoples Hospital
Study Overview
Official Title:
Magnetic Resonance Spectroscopic Imaging Evaluation for Understanding Acute Minor Stroke With Large Vessel Occlusion Evolution Study
Status:
RECRUITING
Status Verified Date:
2024-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MINORITY
Brief Summary:
The goal of this observational study is to understand acute anterior circulation large artery occluded minor stroke LVO-MIS evolution using magnetic resonance spectroscopic imaging evaluation The main questions it aims to answer are
1 Neurometabolic predictors of early neurological deterioration and functional outcome
2 Temporal and spatial dynamic changes of the neurometabolites from the acute stage within 24 hours through the subacute stage 5-7 days to the chronic stage 90 days
3 Temporal and spatial dynamic changes of the neurotransmitters GABA glutamate and glutamine from the acute stage to the chronic stage
4 Brain regions exhibiting changes in whole-brain metabolic network connectivity
1 Neurometabolic predictors of early neurological deterioration and functional outcome
2 Temporal and spatial dynamic changes of the neurometabolites from the acute stage within 24 hours through the subacute stage 5-7 days to the chronic stage 90 days
3 Temporal and spatial dynamic changes of the neurotransmitters GABA glutamate and glutamine from the acute stage to the chronic stage
4 Brain regions exhibiting changes in whole-brain metabolic network connectivity
Detailed Description:
Minor acute ischemic stroke AIS is a common medical condition accounting for more than 50 of AIS Of the patients with minor AIS 283 are unable to discharge home and 285 cannot walk independently Although most patients with large vessel occlusion LVO strokes and mild symptoms have good clinical outcomes individuals with early neurological worsening tend to do poorly despite rescue thrombectomy Therefore it would be ideal to understand the factors associated with acute neurological deterioration 4 NIHSS points among this population to potentially triage higher risk individuals to upfront endovascular therapy
The main goal of this study was to investigate the spatial and temporal changes of neurometabolite concentrations in patients with acute mild ischemic stroke with large vessel occlusion LVO-MIS and to assess the extent to which the combination of all neurometabolite signals measured by 3D-MRSI could discriminate between early neurologic deterioration END and non-END patients
Patients who are older than 18 years of age diagnosed with acute mild ischemic stroke with large vessel occlusion LVO-MIS within 24 hours of onset will be enrolled into the study MRSI will be performed in enrolled stroke patients from the acute stage within 24 hours through the subacute stage 5-7 days to the chronic stage 90 days Higher resolution 3D MRSI scans were performed using SPICE The acquisition parameters were as follows TR 160 msec TE 16 msec spatial resolution 20 30 30 mm3 FOV 240 240 120 mm3 scan time 1835 min
The main goal of this study was to investigate the spatial and temporal changes of neurometabolite concentrations in patients with acute mild ischemic stroke with large vessel occlusion LVO-MIS and to assess the extent to which the combination of all neurometabolite signals measured by 3D-MRSI could discriminate between early neurologic deterioration END and non-END patients
Patients who are older than 18 years of age diagnosed with acute mild ischemic stroke with large vessel occlusion LVO-MIS within 24 hours of onset will be enrolled into the study MRSI will be performed in enrolled stroke patients from the acute stage within 24 hours through the subacute stage 5-7 days to the chronic stage 90 days Higher resolution 3D MRSI scans were performed using SPICE The acquisition parameters were as follows TR 160 msec TE 16 msec spatial resolution 20 30 30 mm3 FOV 240 240 120 mm3 scan time 1835 min
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None