Ignite Creation Date:
2024-06-16 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06459622
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-14
First Post:
2024-03-31
Brief Title:
Predictive Factors in Chronic Rhinosinusitis With Nasal Polyps
Sponsor:
Katrina Atef Habashy
Organization:
Assiut University
Study Overview
Official Title:
Predictive Factors in Chronic Rhinosinusitis With Nasal Polyps
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study will be conducted to identify factors predicting the response of chronic rhinosinusitis with nasal polyps CRSwNP to oral corticosteroids
Detailed Description:
Treatment of nasal polyposis is divided into medical or surgical treatment
Steroids are widely used as the most effective medicine in nasal polyposis Although oral corticosteroids are one of the frequently used treatments in the management of chronic rhinosinusitis with nasal polyps CRSwNP there is lack of effective means of predicting corticosteroid sensitivity in those patients It was reported that the overall sensitivity rates of corticosteroid therapy to nasal polyps NP were only between 538 and 80 Many reports stated that serum and tissue interleukeine 25 IL 25 and serum and tissue eosinophalia are good predictors to the response of CRSwNP to oral corticosteroids
Interleukeine 25IL-25 an important epithelial-derived proinflammatory cytokine plays various roles in different inflammatory and allergic diseases such as asthma and atopic dermatitis
Hong et al demonstrated that the levels of IL-25 in NP tissues and in serum as well as the NP endoscopic scores were significantly elevated in the corticosteroid-sensitive patients compared with the non-sensitive ones In general eosinophilic NPs are pharmacologically glucocorticoid responsive but non-eosinophilic or neutrophilic CRSwNP is frequently resistant to steroid treatment
Steroids are widely used as the most effective medicine in nasal polyposis Although oral corticosteroids are one of the frequently used treatments in the management of chronic rhinosinusitis with nasal polyps CRSwNP there is lack of effective means of predicting corticosteroid sensitivity in those patients It was reported that the overall sensitivity rates of corticosteroid therapy to nasal polyps NP were only between 538 and 80 Many reports stated that serum and tissue interleukeine 25 IL 25 and serum and tissue eosinophalia are good predictors to the response of CRSwNP to oral corticosteroids
Interleukeine 25IL-25 an important epithelial-derived proinflammatory cytokine plays various roles in different inflammatory and allergic diseases such as asthma and atopic dermatitis
Hong et al demonstrated that the levels of IL-25 in NP tissues and in serum as well as the NP endoscopic scores were significantly elevated in the corticosteroid-sensitive patients compared with the non-sensitive ones In general eosinophilic NPs are pharmacologically glucocorticoid responsive but non-eosinophilic or neutrophilic CRSwNP is frequently resistant to steroid treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None