Ignite Creation Date:
2024-06-16 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06457282
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-13
First Post:
2024-06-08
Brief Title:
Studying The Association Between Environmental Exposure to PFAS and Breast Cancer in Assiut Governorate- Egypt
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Studying The Association Between Environmental Exposure to Polyfluoroalkyl Substances and Breast Cancer in Assiut Governorate- Egypt
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
1 Measuring serum level of PFAS in breast cancer female patients and healthy participants
2 Studying the correlation between serum level of PFAS and breast cancer risk through statistical modeling and analysis
3 Studying the magnitude of environmental exposure through measuring levels of PFAS in air and water sources of corresponding participants
2 Studying the correlation between serum level of PFAS and breast cancer risk through statistical modeling and analysis
3 Studying the magnitude of environmental exposure through measuring levels of PFAS in air and water sources of corresponding participants
Detailed Description:
Perfluoroalkyl substances PFASs are persistent pollutants that are present in the environment
Perfluorooctanoic acid PFOA and perfluorooctane sulfonate PFOS known as the most detected per- and polyfluoroalkyl substances PFASin various environmental compartmentsThey have been associated with plastic pollution and endocrine dysfunction
Humans are exposed to PFASs through various pathways including dietary items such as seafood drinking water and some dental floss Contaminated drinking water and food supply are potential sources of 0ral exposure to PFAS PFASs have been used in various products such as firefighting foams surfactants non-stick pans food contact materials such as boxes bags wrappers cups Lim 2019 and table wares and personal care products including cosmetics
Over the past 180 years 1839-2019 numerous emerging contaminants have been identified Perfluorooctanoic acid PFOA and perfluoro octane sulfonate PFOS are two of the most used PFAS compounds in various applications and have already been identified as endocrine-disrupting chemicalsEDCs
Due to their structural and functional similarities with endogenous steroid hormones EDCs mimic and interfere with homeostatic mechanisms and signaling pathways of hormones in the body even at low concentrations They cause a variety of endocrine and metabolic disorders developmental abnormalities and hormone-dependent cancers
PFAS exhibits a wide range of toxic effects including developmental toxicity genotoxicity carcinogenicity hepatotoxicity reproductive toxicity immunotoxicity cytotoxicity neurotoxicity and hormonal toxicity
Moreover the International Agency for Research on Cancer IARC has classified PFOA as possibly carcinogenic to humans
Breast cancer is one of the major female health problems worldwide Although there is growing evidence indicating that pollution increases the risk of breast cancer there is still inconsistency among previous studies
As we mentioned before that PFAS is considered as EDCso it may interact with estrogen receptors ATSDR 2018 And multiple studies found association between PFOS exposure and decreasd serum or saliva concentrations of estrogen in women
It is well known that breast cancer is hormone-dependent its development may be associated with exposure to xenoestrogens found in environmental pollutants Adami et al 2018
Multiple epidemiological Morgan et al 2017 and experimental studies Pierozan et al 2018 Pierozan and Karlsson 2018 have associated EDC exposure with increased risk of breast cancer and breast cancer metastasisExposure to some PFASs has been both positively Mancini et al 2020 Tsai et al 2020 associated with breast cancer risk as in Greenlandic Inuit womenand inversely associated with breast cancer risk as inTaiwanese women
The presented study will be the first study to be done in Egypt to study the risk of PFAS environmental exposure and its correlation to breast cancer Currently there is no information available on the production use management and bio persistence of PFAS substances in Egypt This is an area that needs attention particularly for substances dispersed directly into the environment such as PFAS And performing a risk assessment study identifying high exposure levels to various PFAS compounds in Assiut Governorate which will help in establishing the PFAS Egyptian toxicological report recommended by the Ministry of Environment as a part of the Stockholm Convention to protect human health and the environment from persistent organic pollutantsWith increasing concerns of climate changes and global warming Egypt proceeded in setting recommendations for PFAS eliminationThese recommendation contributes to the achievement of several key Sustainable Development Goals SDGs due to the impacts of the substances on health and ecosystems including water pollution
Perfluorooctanoic acid PFOA and perfluorooctane sulfonate PFOS known as the most detected per- and polyfluoroalkyl substances PFASin various environmental compartmentsThey have been associated with plastic pollution and endocrine dysfunction
Humans are exposed to PFASs through various pathways including dietary items such as seafood drinking water and some dental floss Contaminated drinking water and food supply are potential sources of 0ral exposure to PFAS PFASs have been used in various products such as firefighting foams surfactants non-stick pans food contact materials such as boxes bags wrappers cups Lim 2019 and table wares and personal care products including cosmetics
Over the past 180 years 1839-2019 numerous emerging contaminants have been identified Perfluorooctanoic acid PFOA and perfluoro octane sulfonate PFOS are two of the most used PFAS compounds in various applications and have already been identified as endocrine-disrupting chemicalsEDCs
Due to their structural and functional similarities with endogenous steroid hormones EDCs mimic and interfere with homeostatic mechanisms and signaling pathways of hormones in the body even at low concentrations They cause a variety of endocrine and metabolic disorders developmental abnormalities and hormone-dependent cancers
PFAS exhibits a wide range of toxic effects including developmental toxicity genotoxicity carcinogenicity hepatotoxicity reproductive toxicity immunotoxicity cytotoxicity neurotoxicity and hormonal toxicity
Moreover the International Agency for Research on Cancer IARC has classified PFOA as possibly carcinogenic to humans
Breast cancer is one of the major female health problems worldwide Although there is growing evidence indicating that pollution increases the risk of breast cancer there is still inconsistency among previous studies
As we mentioned before that PFAS is considered as EDCso it may interact with estrogen receptors ATSDR 2018 And multiple studies found association between PFOS exposure and decreasd serum or saliva concentrations of estrogen in women
It is well known that breast cancer is hormone-dependent its development may be associated with exposure to xenoestrogens found in environmental pollutants Adami et al 2018
Multiple epidemiological Morgan et al 2017 and experimental studies Pierozan et al 2018 Pierozan and Karlsson 2018 have associated EDC exposure with increased risk of breast cancer and breast cancer metastasisExposure to some PFASs has been both positively Mancini et al 2020 Tsai et al 2020 associated with breast cancer risk as in Greenlandic Inuit womenand inversely associated with breast cancer risk as inTaiwanese women
The presented study will be the first study to be done in Egypt to study the risk of PFAS environmental exposure and its correlation to breast cancer Currently there is no information available on the production use management and bio persistence of PFAS substances in Egypt This is an area that needs attention particularly for substances dispersed directly into the environment such as PFAS And performing a risk assessment study identifying high exposure levels to various PFAS compounds in Assiut Governorate which will help in establishing the PFAS Egyptian toxicological report recommended by the Ministry of Environment as a part of the Stockholm Convention to protect human health and the environment from persistent organic pollutantsWith increasing concerns of climate changes and global warming Egypt proceeded in setting recommendations for PFAS eliminationThese recommendation contributes to the achievement of several key Sustainable Development Goals SDGs due to the impacts of the substances on health and ecosystems including water pollution
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None