Ignite Creation Date:
2024-06-16 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06454344
Status:
RECRUITING
Last Update Posted:
2024-06-25
First Post:
2024-06-03
Brief Title:
The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies
Sponsor:
Nathaniel Jenkins
Organization:
University of Iowa
Study Overview
Official Title:
Associations of Adverse Childhood Experiences Sleep Disruption and Vascular Dysfunction in Young Adults The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies
Status:
RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The overall purpose of this study is to understand the role of disrupted sleep in the association of exposure to early life adversity adverse childhood experiences ACEs with vascular endothelial dysfunction
In Aim 1 The Iowa ACEs and Sleep Cohort Study the investigators will utilize a cross-sectional cohort design with a state-of-the-art translational approach Participants will be recruited to objectively characterize the degree to which lower sleep quality and quantity contribute to ACEs-related endothelial dysfunction inflammation and oxidative stress in young adults using
1 rigorous at home sleep monitoring using 7-nights of wrist actigraphy and 2 nights of home-based polysomnography to objectively measure sleep quality sleep efficiency wakefulness after sleep onset and sleep depth and total sleep duration
2 in vivo assessment of endothelial function via flow-mediated dilation testing and
3 in vitro determination of endothelial cell inflammation and oxidative stress from biopsied endothelial cells This study to achieve this Aim
In Aim 2 approximately 70 eligible participants from Aim 1 The Iowa ACEs and Sleep Cohort Study will then be randomized to either a 6-week behavioral sleep intervention cognitive behavioral therapy for insomnia or a wait-list control to determine the mechanistic contribution of sleep disruption to vascular dysfunction in young adults with moderate-to-high exposure to adverse childhood experiences ACEs Following the intervention participants will again complete
1 rigorous at home sleep monitoring using 7-nights of wrist actigraphy and 2 nights of home-based polysomnography to objectively measure sleep quality sleep efficiency wakefulness after sleep onset and sleep depth and total sleep duration
2 in vivo assessment of endothelial function via flow-mediated dilation testing and
3 in vitro determination of endothelial cell inflammation and oxidative stress from biopsied endothelial cells
In Aim 1 The Iowa ACEs and Sleep Cohort Study the investigators will utilize a cross-sectional cohort design with a state-of-the-art translational approach Participants will be recruited to objectively characterize the degree to which lower sleep quality and quantity contribute to ACEs-related endothelial dysfunction inflammation and oxidative stress in young adults using
1 rigorous at home sleep monitoring using 7-nights of wrist actigraphy and 2 nights of home-based polysomnography to objectively measure sleep quality sleep efficiency wakefulness after sleep onset and sleep depth and total sleep duration
2 in vivo assessment of endothelial function via flow-mediated dilation testing and
3 in vitro determination of endothelial cell inflammation and oxidative stress from biopsied endothelial cells This study to achieve this Aim
In Aim 2 approximately 70 eligible participants from Aim 1 The Iowa ACEs and Sleep Cohort Study will then be randomized to either a 6-week behavioral sleep intervention cognitive behavioral therapy for insomnia or a wait-list control to determine the mechanistic contribution of sleep disruption to vascular dysfunction in young adults with moderate-to-high exposure to adverse childhood experiences ACEs Following the intervention participants will again complete
1 rigorous at home sleep monitoring using 7-nights of wrist actigraphy and 2 nights of home-based polysomnography to objectively measure sleep quality sleep efficiency wakefulness after sleep onset and sleep depth and total sleep duration
2 in vivo assessment of endothelial function via flow-mediated dilation testing and
3 in vitro determination of endothelial cell inflammation and oxidative stress from biopsied endothelial cells
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None