Ignite Creation Date:
2024-06-16 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06453993
Status:
COMPLETED
Last Update Posted:
2024-06-12
First Post:
2024-03-11
Brief Title:
Temporal Variation in Exhaled Volatile Organic Compounds in Esophageal Cancer Patients
Sponsor:
Benaroya Research Institute
Organization:
Benaroya Research Institute
Study Overview
Official Title:
Temporal Variation in Exhaled Volatile Organic Compounds in Response to Therapeutic Intervention in Esophageal Cancer Patients
Status:
COMPLETED
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate whether exhaled breath can be used to detect and monitor esophageal cancer
Detailed Description:
Esophageal cancer EG cancer affects over half a millions people worldwide every year Early esophageal cancer typically has non-specific symptoms that are often mistaken for benign non-cancer conditions As a result patients are often referred for further investigations only when they have more prominent symptoms that are typically associated with advanced incurable disease As a consequence 7 out of 10 new cases of EG cancer diagnosed are considered to be at an advanced stage with less than 1 in 3 patients eligible for potentially curative therapy Better ways of diagnosing esophageal cancer earlier are therefore needed An ideal test for esophageal cancer would be non-invasive simple to administer in the community and cost effective
The investigators approach to this clinical challenge is to establish a non-invasive test for the detection of esophageal cancer that is based upon the unique signature of small molecules within exhaled breath In this study that is being conducted in collaboration with researchers in the United Kingdom UK the investigators would like to measure the levels of these small molecules within the breath of patients with esophageal cancer at different times during their treatment i at diagnosis ii after chemoradiotherapy and iii after surgery By studying how the small molecules contained within the breath change as a result of esophageal cancer and its treatment the investigators hope to learn new information that can help develop a new test for this disease
The investigators will also measure the small molecules within saliva and urine samples collected at the same time as breath in order to study if there are any important differences between these three samples The investigators will also attempt to measure different bacteria
The investigators approach to this clinical challenge is to establish a non-invasive test for the detection of esophageal cancer that is based upon the unique signature of small molecules within exhaled breath In this study that is being conducted in collaboration with researchers in the United Kingdom UK the investigators would like to measure the levels of these small molecules within the breath of patients with esophageal cancer at different times during their treatment i at diagnosis ii after chemoradiotherapy and iii after surgery By studying how the small molecules contained within the breath change as a result of esophageal cancer and its treatment the investigators hope to learn new information that can help develop a new test for this disease
The investigators will also measure the small molecules within saliva and urine samples collected at the same time as breath in order to study if there are any important differences between these three samples The investigators will also attempt to measure different bacteria
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None