Ignite Creation Date:
2024-06-16 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06457945
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-13
First Post:
2024-05-31
Brief Title:
Mind-wandering and Predictive Processes in Narcolepsy a Putative Mechanism Through Covert REM Intrusions
Sponsor:
Hospices Civils de Lyon
Organization:
Hospices Civils de Lyon
Study Overview
Official Title:
Mind-wandering and Predictive Processes in Narcolepsy a Putative Mechanism Through Covert REM Intrusions the NarcoWandering Study
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
NARCOWANDERING
Brief Summary:
Mind wandering is a state in which attention turns away from the external environment or current task to focus on internal thoughts past experiences future events planned actions Humans are thought to spend at least one third of their waking lives in this state Mind wandering can be assessed experimentally by investigating mental content during well-controlled tasks In this case task-unrelated thoughts likely to arise during tasks of varying cognitive demand are studied Mind wandering task-unrelated thoughts has a deleterious effect on cognitive performance in most paradigms particularly those requiring sustained attention and executive control However this phenomenon could also have cognitive benefits although knowledge on this issue remains limited For example it has been suggested that mind wandering could promote creativity anticipation of future scenarios and prospective memory In a recent behavioural study we investigated the cost and benefit of mind wandering in an implicit visual-motor probabilistic learning task ASRT - Alternating Serial Reaction Time Task ASRT distinguishes between two fundamental processes visuomotor performance and implicit statistical learning While the former reflects visuo-spatial discrimination efficiency the latter refers to the unintentional acquisition of probabilistic regularities of external inputs Reduced visuo-spatial accuracy and faster but less accurate responses have been observed during periods of mind-wandering On the other hand mind-wandering was associated with enhanced statistical learning reflecting improved predictive processing
Whereas the study of the neural correlates of mind-wandering is constantly growing the mechanisms triggering mind-wandering are far from being unravelled but may involve sleep pressure Thus the frequency of mind wandering tends to increase after sleep deprivation or during attention-demanding cognitive tasks during which neurophysiological markers of local sleep appear These markers of sleep during wakefulness are frequently observed in hypersomnolence disorders They are generally defined by the appearance of slow waves typical of slow wave sleep SWS Nevertheless sleep intrusions during wakefulness may not be limited to non-rapid-eye-movement NREM sleep but also concern REM sleep REM sleep is the sleep state when the most intense forms of dreaming occur and could therefore be phenomenologically similar to the reverie of mind wandering Thus daytime mental wandering could be triggered by intrusions of REM sleep during wakefulness
Patients with narcolepsy type 1 NT1 exhibit frequent REM sleep onset during daytime wakefulness The study of ASRT in this population therefore offers a unique opportunity to investigate the role of REM sleep intrusions in mind wandering The hypothesis is that mind wandering would be observed more frequently during the ASRT task in NT1 patients with REM sleep intrusions during wakefulness than in patients with idiopathic hypersomnia IH with NREM sleep intrusions during wakefulness and patients with subjective hypersomnolence little or no sleep intrusion Furthermore it could be possible that REM sleep-related mind wandering would be associated with impaired visuomotor performance in terms of accuracy but improved predictive processing probabilistic learning compared to NREM sleep intrusions or no sleep intrusion during the task
Whereas the study of the neural correlates of mind-wandering is constantly growing the mechanisms triggering mind-wandering are far from being unravelled but may involve sleep pressure Thus the frequency of mind wandering tends to increase after sleep deprivation or during attention-demanding cognitive tasks during which neurophysiological markers of local sleep appear These markers of sleep during wakefulness are frequently observed in hypersomnolence disorders They are generally defined by the appearance of slow waves typical of slow wave sleep SWS Nevertheless sleep intrusions during wakefulness may not be limited to non-rapid-eye-movement NREM sleep but also concern REM sleep REM sleep is the sleep state when the most intense forms of dreaming occur and could therefore be phenomenologically similar to the reverie of mind wandering Thus daytime mental wandering could be triggered by intrusions of REM sleep during wakefulness
Patients with narcolepsy type 1 NT1 exhibit frequent REM sleep onset during daytime wakefulness The study of ASRT in this population therefore offers a unique opportunity to investigate the role of REM sleep intrusions in mind wandering The hypothesis is that mind wandering would be observed more frequently during the ASRT task in NT1 patients with REM sleep intrusions during wakefulness than in patients with idiopathic hypersomnia IH with NREM sleep intrusions during wakefulness and patients with subjective hypersomnolence little or no sleep intrusion Furthermore it could be possible that REM sleep-related mind wandering would be associated with impaired visuomotor performance in terms of accuracy but improved predictive processing probabilistic learning compared to NREM sleep intrusions or no sleep intrusion during the task
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None