Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06452862
Status:
RECRUITING
Last Update Posted:
2024-06-11
First Post:
2024-06-05
Brief Title:
Multimodal Magnetic Resonance Imaging in Evaluation of Diabetic Kidney Disease
Sponsor:
Shengjing Hospital
Organization:
Shengjing Hospital
Study Overview
Official Title:
the Value of Multimodal Magnetic Resonance Imaging in the Diagnosis and Treatment Monitoring of Diabetic Kidney Disease
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this study is to investigate the value of noninvasive evaluation of multimodal magnetic resonance imaging in diagnosis and treatment of diabetic kidney disease DKD We aim to explore the feasibility of multimodal magnetic resonance imaging in the staging diagnosis of DKD and establish a non-invasive method for evaluating the progression of DKD disease by combining imaging and biochemical indicators Multimodal magnetic resonance examinations will be performed on diabetic patients with different stages as well as regular follow-up during treatment in order to investigate the relationship between imaging findings and pathophysiological changes of the kidneys
Detailed Description:
At present the clinical diagnosis of diabetic kidney disease DKD relies mainly on the detection of urine microalbuminwhich is influenced by many other factors Renal biopsy is another modality to detect DKD but it cannot be widely used in clinical practice because of its invasiveness Thus a reproducible and reliable noninvasive method is needed for more accurate diagnosis
Multimodal magnetic resonance imaging which including but not limited to magnetic resonance elastography MRE blood oxygen level-dependent magnetic resonance imaging BOLD-MRI arterial spin labeling ASL incoherent motion diffusion-weighted imaging IVIM-DWI T1mapping and T2mapping is able to provide valuable information about subtle structural and functional changes and has shown promising potential in the diagnosis classification and prediction of pathological and molecular features
In this clinical trial multimodal magnetic resonance examinations will be performed on diabetic patients with different stages as well as regular follow-up during treatment in order to investigate the relationship between imaging findings and pathophysiological changes of the kidneys We aim to explore the feasibility of multimodal magnetic resonance imaging in the staging diagnosis of DKD and establish a non-invasive method for evaluating the progression of DKD disease by combining imaging and biochemical indicators in order to provide reference for clinical medication This research could be helpful for better understanding and management of DKD and pave the way for more accurate diagnosis improved clinical decision-making personalized treatment approaches for DKD patients
Multimodal magnetic resonance imaging which including but not limited to magnetic resonance elastography MRE blood oxygen level-dependent magnetic resonance imaging BOLD-MRI arterial spin labeling ASL incoherent motion diffusion-weighted imaging IVIM-DWI T1mapping and T2mapping is able to provide valuable information about subtle structural and functional changes and has shown promising potential in the diagnosis classification and prediction of pathological and molecular features
In this clinical trial multimodal magnetic resonance examinations will be performed on diabetic patients with different stages as well as regular follow-up during treatment in order to investigate the relationship between imaging findings and pathophysiological changes of the kidneys We aim to explore the feasibility of multimodal magnetic resonance imaging in the staging diagnosis of DKD and establish a non-invasive method for evaluating the progression of DKD disease by combining imaging and biochemical indicators in order to provide reference for clinical medication This research could be helpful for better understanding and management of DKD and pave the way for more accurate diagnosis improved clinical decision-making personalized treatment approaches for DKD patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None