Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06457399
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-06-13
First Post:
2024-05-30
Brief Title:
Heliox on the Work of Breathing in Adult Patients With Lower Airway Stenosis
Sponsor:
Hospital Universitario 12 de Octubre
Organization:
Hospital Universitario 12 de Octubre
Study Overview
Official Title:
The Effect of Heliox on the Work of Breathing in Adult Patients With Lower Airway Stenosis
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Heliox a mixture of Helium and Oxygen can reduce the work of breathing in patients with airway stenosis by modifying turbulent flow into laminar flow The aim of this study was to analyze the effect of Heliox versus conventional oxygen therapy in patients with lower airway stenosis on muscular effort measured by electromyography and diaphragmatic ultrasound thoracoabdominal synchrony assessed with plethysmographic bands dyspnea stridor oxygen saturation transcutaneous carbon dioxide value blood pressure heart rate and respiratory rate
Detailed Description:
Lower airway stenosis results in increased work of breathing with stridor and dyspnea as a consequence of the increased resistances caused by the reduction in airway diameter Airway resistance also depends on the length of the airway and the type of gas flow Heliox a mixture of Helium and Oxygen is a gas less dense than air which can change the flow from turbulent to laminar reducing airway resistance by 20 to 40 and therefore decreasing the work of breathing Heliox is an inert gas that does not react with biological membranes so there are few complications associated with its use the most relevant being hypoxemia when fixed mixtures are not used and the the fraction of inspired oxygen FiO2 supplied is less than 21 The aim of the study was to evaluate if during the perioperative period of lower airway stenosis the administration of Heliox compared to oxygen could reduce the work of breathing and improve dyspnea For this purpose patients were treated for 30 minutes with Heliox fixed mixture of 70 helium and 30 oxygen using a non rebreather mask or reservoir bag versus 30 minutes with oxygen 31 using a Venturi mask
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None