Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06454825
Status:
COMPLETED
Last Update Posted:
2024-06-12
First Post:
2024-06-01
Brief Title:
Effects of Antiemetic Agents in Orthognathic Surgery Patients
Sponsor:
Bezmialem Vakif University
Organization:
Bezmialem Vakif University
Study Overview
Official Title:
Effects of Combined Antiemetic Protocol For The Prevention Of Postoperative Nausea And Vomiting In Orthognathic Surgery A Randomized Double Blinded Clinical Study
Status:
COMPLETED
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In an effort to prevent or treat consistently high rates of PONV following maxillofacial operations several medications techniques and multimodal protocols have been studied In the present study the investigators hypothesized that combining metoclopramide with granisetron will improve PONV incidence when compared with granisetrone alone
Detailed Description:
Despite advances in anesthetic techniques and antiemetic drugs that accompany increasing awareness of anesthesia providers postoperative nausea and vomiting PONV remains one of the most common problems after general anesthesia PONV is one of the major problems leading to patient dissatisfaction prolonged stay in postoperative care unit and hospital readmissions and thus it can increase health care costs In the studies performed in PONV prone patients and high-risk surgeries as compared with other antiemetic medications setrons provided lower nausea and vomiting incidence postoperatively but were unable to completely prevent this big little problemThe blood in the stomach has been indicated as one of the major causes of PONV following maxillofacial surgery thus using metoclopramide may relieve the complaints by evacuating this irritant After institutional ethic committee and National Medicines 66 consecutive patients classified as ASA I and II physical status and aged between 18 and 60 years were included in the study Apfels simplified PONV risk score including female sex history of motion sickness or PONV smoking status and predicted use of postoperative opioids was recordedProcedures were performed under general anesthesia Patients in Group G received 3 mg granisetron Neoset Deva Istanbul and the patients in group GM received 3 mg granisetron 10 mg metoclopramide Metpamid Sifar İlaç Istanbul 30 minutes before the end of operation intravenously A nursing staff collected the data concerning PONV VAS systolic diastolic and mean arterial pressures heart rate peripheral arterial saturation total doses of drugs used overall bleeding score infused fluid volume VAS surgical procedure duration of surgery and rescue antiemetics for nausea if applied for 24 hours
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None