Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06452251
Status:
COMPLETED
Last Update Posted:
2024-06-14
First Post:
2024-05-30
Brief Title:
Vitamin-D Insufficiency and Implants
Sponsor:
Vesile Elif Toy
Organization:
Inonu University
Study Overview
Official Title:
Vitamin-D Insufficiency Leads to Interleukin-10 Reduction in Peri-implant Tissues A Case-Control Study
Status:
COMPLETED
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Vitamin D is important for bone health immune function and inflammation along with dental implant success The study aimed to assess bone markers and cytokine levels in patients with and without vitamin D insufficiency to better understand the effects of vitamin D levels on dental implant integration The study included 42 patients in 2 groups with insufficient Group IN-S n21 and sufficient Group S n21 levels of vitamin D Bone remodelling proinflammatory and antiinflammatory markers were analyzed in bone and peri-implant crevicular fluid PICF using enzyme-linked immunosorbent assay ELISA and results were reported as concentration and total amount
Detailed Description:
Background Vitamin D is crucial for bone mineralization and plays a significant role in immune and inflammatory responses Its deficiency is highly prevalent and might alter osseointegration of dental implants Since successful osseointegration is a critical aspect of implant survival and the effects of vitamin D on implant osseointegration have not been well documented the aim of this study was to evaluate bone markers and cytokine levels of patients with or without vitamin D insufficiency Methods A total of 42 patients were included and divided into two groups Vitamin D insufficient Group IN-S n21 and Vitamin D sufficient Group S n21 Besides clinical periodontal parameters and implant stability measurements bone and peri-implant crevicular fluid PICF levels of Receptor Activator of Nuclear Factor Kappa B Ligand RANKL osteoprotegerin OPG osteocalcin OC calcium Ca tumour necrosis factor alpha TNF-α Interleukin 1β IL-1β caspase-1 and Interleukin 10 IL-10 were determined by enzyme-linked immunosorbent assay ELISA Results were represented as concentration and total amount
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None