Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06455917
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-12
First Post:
2024-06-06
Brief Title:
TIL Therapy in Non-small-cell Lung Cancer NSCLC Patients
Sponsor:
University Hospital Basel Switzerland
Organization:
University Hospital Basel Switzerland
Study Overview
Official Title:
A Phase II Trial of Adoptive Cell Therapy With Tumor-infiltrating Lymphocytes in Patients With Non-Small Cell Lung Cancer
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
BaseTIL-02
Brief Summary:
Aim of the study is to investigate the efficacy and safety of Adoptive cell therapy ACT with tumor-infiltrating lymphocytes TILs in NSCLC patients in a phase II clinical trial
Detailed Description:
Adoptive cell therapy ACT with tumor-infiltrating lymphocytes TILs is a personalized immunotherapy In patients with advanced Non-Small Cell Lung Cancer NSCLC a phase I clinical trial has investigated TIL-ACT in patients who progressed during ICI-treatment
For TIL-ACT tumor-specific T cells are expanded from excised tumor samples and stimulated in cell culture with interleukin-2 IL-2 The resulting autologous TILs are then re-infused to the patient after a non-myeloablative lymphodepleting chemotherapy with cyclophosphamide and fludarabine Activation of TILs in the patient is then supported by IL-2 administration
For TIL-ACT tumor-specific T cells are expanded from excised tumor samples and stimulated in cell culture with interleukin-2 IL-2 The resulting autologous TILs are then re-infused to the patient after a non-myeloablative lymphodepleting chemotherapy with cyclophosphamide and fludarabine Activation of TILs in the patient is then supported by IL-2 administration
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None