Viewing Study NCT06458153



Ignite Creation Date: 2024-06-16 @ 11:52 AM
Last Modification Date: 2024-10-26 @ 3:32 PM
Study NCT ID: NCT06458153
Status: NOT_YET_RECRUITING
Last Update Posted: 2024-06-13
First Post: 2024-06-03

Brief Title: Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
Sponsor: University of Pittsburgh
Organization: University of Pittsburgh

Study Overview

Official Title: High-resolution Functional Imaging of Speech-induced Sensory Modulation
Status: NOT_YET_RECRUITING
Status Verified Date: 2024-06
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes The main questions it aims to answer are

1 What regions of the brains sensory systems show changes in their activity related to speech
2 To what extent do these regions help listeners detect and correct speech errors
3 What is the role of the cerebellum a part of the brain in the back of the head in these activities

Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography EEG and functional magnetic resonance imaging fMRI
Detailed Description: This study aims to provide an integrated view of brain systems underlying predictive coding in speech with unprecedented detail using ultra-high field 7 Tesla functional magnetic resonance imaging The overall approach is a condition-intensive within-subjects design with extensive sampling of individual participants including a group who have had strokes impacting the cerebellum across multiple sessions

Participants will be asked to complete up to 6 sessions Passing a hearing assessment using standard audiological procedures conducted at the start of the first session is a requirement for participation The experimental sessions involve behavior and non-invasive brain imaging

Investigators will ask participants to perform several short tasks to measure different aspects of their speech production and speech perception eg reading passages or words aloud making judgements about sounds

In one session Investigators will measure electroencephalography EEG while participants complete tasks involving producing and hearing speech sounds Participants will be fitted with an elastic cap and up to 32 non-invasive recording electrodes

In other sessions investigators will measure structural and functional magnetic resonance imaging fMRI Structural images demonstrate the unique brain anatomy of the participant Functional images will be obtained while the participant completes specific tasks involving listening speaking or completing other motor actions eg pressing a button All participants will be screened for MRI risk factors prior to each session

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: False
Is a FDA Regulated Device?: False
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None
Secondary IDs
Secondary ID Type Domain Link
1R01DC020963-01A1 NIH None httpsreporternihgovquickSearch1R01DC020963-01A1