Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:31 PM
Study NCT ID:
NCT06451744
Status:
RECRUITING
Last Update Posted:
2024-07-11
First Post:
2023-07-06
Brief Title:
Cellular and Molecular Biomarkers in Patients With Lichen Planus
Sponsor:
Institut Pasteur
Organization:
Institut Pasteur
Study Overview
Official Title:
Evaluation of the Clinical Specificity of Cellular and Molecular Biomarkers Identified in Patients With Lichen Planus
Status:
RECRUITING
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HELP
Brief Summary:
Lichen planus LP is a chronic inflammatory disease of unknown aetiology affecting the skin and mucous membranes characterised by a CD8 cytotoxic T-cell infiltrate associated with epithelial cell death and disruption of the basement membrane zone In previous work T cell antigen receptor TCR repertoire studies were performed In all patients tested whether with erosive or non-erosive LP unique nucleotide sequences called clonotypes have been identified They appear during the process of TCR gene rearrangement These clonotypes are specific for human papillomavirus HPV in blood and lesions suggesting antigenic stimulation of these clonotypes by a viral epitope of HPV which crosses with an epitope on keratinocytes The diagnosis of LP is made on the basis of clinical and histological criteria but in some patients and in some anatomical locations the diagnosis is difficult to make and LP may be confused with other skin conditions
Detailed Description:
Lichen planus LP is a chronic inflammatory disease of unknown aetiology affecting the skin and mucous membranes characterised by a CD8 cytotoxic T-cell infiltrate associated with epithelial cell death and disruption of the basement membrane zone Several triggers have been proposed for LP including viral antigens In previous work T cell antigen receptor TCR repertoire studies were performed ie investigating the diversity of TCRs expressed on the surface of an individuals lymphocyte population In all patients tested whether with erosive or non-erosive LP unique nucleotide sequences called clonotypes have been identified They appear during the process of TCR gene rearrangement These clonotypes are specific for human papillomavirus HPV in blood and lesions suggesting antigenic stimulation of these clonotypes by a viral epitope of HPV which crosses with an epitope on keratinocytes The diagnosis of LP is made on the basis of clinical and histological criteria but in some patients and in some anatomical locations the diagnosis is difficult to make and LP may be confused with other skin conditions
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None