Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06458504
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-06-13
First Post:
2024-06-10
Brief Title:
Viral Infection of HSPC Impacts Hematopoiesis
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Virus-induced Immunosuppression Via Infection of Hematopoietic Progenitors
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MEGAHOST
Brief Summary:
We propose to demonstrate that HIV-1 and SARS-CoV-2 are capable of targeting long-lived HSPC with self-renewal capacities These progenitors thus transformed into host cells can give rise to a durable source of infected cells with an impact on hematopoiesis
Detailed Description:
Virus-induced immunosuppression is the transient or persistent decline of immune cell counts andor function caused by a virus favouring its persistence in the host organisms When sustained triggered by acute viral replication or maintained by chronic viral infections virus-induced immunosuppression is a life-threatening condition It is notoriously observed in chronic HIV-1 infection and even in a considerable fraction of antiretroviral-treated HIV-infected individuals It is also observed in some individuals recovering from severe and mild-to-moderate COVID-19 Its mechanisms are elusive and efficient therapeutic options are not available Virus-induced immunosuppression may occur in the periphery affecting circulating immune cells or in the bone marrow affecting hematopoietic stem and progenitor cells HSPC and hematopoiesis Several viruses can infect HSPCs HIV-1 can directly infect HSC negatively impacting HSC function and the whole stem cell environment of the bone marrow Whether HSC can be productively infected by SARS-CoV-2 or just targeted and modulated by it remains uncertain and further studies are required to determine HSPC susceptibility or viral sensing for SARS-CoV-2 Therefore we will i Evaluate which hematopoietic stem and progenitor cells HSPC are targeted by HIV-1 in vivo and ex vivo and SARS-CoV-2 ex vivo ii Evaluate whether these infected HSPC would modulate the bone marrow environment by upregulating inflammatory cytokines detrimental to lymphopoiesis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2024-A00117-40 | REGISTRY | IDRCB | None |