Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06457243
Status:
RECRUITING
Last Update Posted:
2024-06-13
First Post:
2024-06-10
Brief Title:
Closed-loop cTBS for the Core Clinical Features of Methamphetamine Use Disorder
Sponsor:
Shanghai Mental Health Center
Organization:
Shanghai Mental Health Center
Study Overview
Official Title:
Closed-loop Neuromodulation Based on Individualised EEG Biomarkers of Methamphetamine Use Disorder
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Using specific EEG biomarkers in methamphetamine-dependent individuals this study systematically probes closed-loop continuous Theta-burst Stimulation cTBS based on brain states assessing dosage neurologic and behavioral effects while comparing its efficacy with traditional open-loop cTBS methods
Detailed Description:
The current study delineates a robust correlation between prefrontal cortex EEG signals and the psychological craving associated with methamphetamine usage Dependents exhibit heightened β oscillation energy in the MPFC region and diminished γ oscillation energy across the DLPFC-MPFC region Previously through the implementation of rTMS interventions on the left DLPFC the investigators have successfully reduced the craving levels in users when exposed to relevant cues coupled with observed decreases in β oscillation energy and increases in γ oscillation energy in the MPFC region This indicates that both β and γ oscillation energies are instrumental in representing the involvement of MPFC and DLPFC during craving episodes and neuromodulatory technologies can modulate these energy levels consequently reducing cravings Furthermore the investigators identified a significant augmentation in the theta energy in the occipital lobe when MA dependents are confronted with drug-related cue imagery signifying a potential crucial neural marker for addiction-induced brain activity Therefore the investigators intend to employ the non-invasive continuous Theta-burst Stimulation cTBS predicated upon biomarkers of addiction states to administer specific frequency stimulations to targeted brain regions aiming to achieve therapeutic objectives in addiction treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None