Ignite Creation Date:
2024-06-16 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 3:32 PM
Study NCT ID:
NCT06460480
Status:
RECRUITING
Last Update Posted:
2024-06-14
First Post:
2024-06-11
Brief Title:
Monitoring After Cardiac Arrest Electroencephalogram and Cerebral Oximetry in Predicting Outcome
Sponsor:
Haseki Training and Research Hospital
Organization:
Haseki Training and Research Hospital
Study Overview
Official Title:
Evaluation of Survival Outcomes After Cardiac Arrest by Monitoring Electroencephalogram Cerebral Oximetry and Serum Biomarkers
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Because of its high incidence it is essential to determine the neurological prognosis after cardiac arrest However there is not much information to guide post-cardiac arrest care Also dynamic monitoring of the state of the brain can help provide information about the patients prognosis other than previously described serum biomarkers Therefore the researchers will monitor postcardiac arrest patients in the intensive care unit for 48 hours by electroencephalogram and cerebral oximetry and collect blood samples for serum biomarkers neuron-specific enolase NSE human neurogranin NRGN and human trigger receptor expressed on myeloid cells TREM-2 which are associated with neuronal damage And investigate the relation of these data to mortality
Detailed Description:
After cardiac resuscitation and intubation the patient will be followed up with electroencephalogram-based monitoring and cerebral oximetry in the ICU for 48 hours As standard post-CPR patients will be sedated with midazolam 002- 01 mgkgs and remifentanil 025- 05 mcqkgmin for 24 hours
Brain function measurements will be recorded under sedation for the first 24 hours and without sedation for the second 24 hours The values recorded were suppression ratio suppression time patient state index oxyhemoglobin and deoxyhemoglobin and regional oxygen saturation After 24 hours a 2 ml blood sample will be taken for biomarkers NSE NRGN TREM-2 Patient survival will be followed up for seven days and 28 days
The demographic data of the patients age gender body mass index ASA scores comorbidities history of previous operations blood pressure heart rate and SpO2 CPR duration the reason for arrest4H4T and inotropic-vasopressor support before and after arrest will be recorded GCS APACHE-2 and SOFA scores will be recorded when the patient is first admitted to the intensive care unit and at the time of cardiac arrest
Brain function measurements will be recorded under sedation for the first 24 hours and without sedation for the second 24 hours The values recorded were suppression ratio suppression time patient state index oxyhemoglobin and deoxyhemoglobin and regional oxygen saturation After 24 hours a 2 ml blood sample will be taken for biomarkers NSE NRGN TREM-2 Patient survival will be followed up for seven days and 28 days
The demographic data of the patients age gender body mass index ASA scores comorbidities history of previous operations blood pressure heart rate and SpO2 CPR duration the reason for arrest4H4T and inotropic-vasopressor support before and after arrest will be recorded GCS APACHE-2 and SOFA scores will be recorded when the patient is first admitted to the intensive care unit and at the time of cardiac arrest
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None