Ignite Creation Date:
2024-07-17 @ 10:41 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06495866
Status:
RECRUITING
Last Update Posted:
2024-07-11
First Post:
2024-07-03
Brief Title:
Ultrasound Assessment of Entheseal Sites in Patients With Seronegative Spondyloarthropathy With or Without Fibromyalgia
Sponsor:
Sohag University
Organization:
Sohag University
Study Overview
Official Title:
Ultrasound Assessment of Entheseal Sites in Patients With Seronegative Spondyloarthropathy With or Without Fibromyalgia
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Seronegative spondyloarthropathies are a family of joint disorders that classically include ankylosing spondylitis AS psoriatic arthritis PsA inflammatory bowel disease IBD associated arthritis reactive arthritis formerly Reiter syndrome ReA and undifferentiated SpA Enthesitis or inflammation of the sites where the tendons or ligaments insert into the bone is a key pathological finding in SpA It is considered the hallmark and characteristic feature of spondyloarthritis SpA Entheses could be classified as fibrous entheses and fibrocartilaginous entheses Regional structural damage such as tendon injuries and bone erosions are frequently caused by persistent enthesitis The healing process that follows may result in the emergence of enthesophytes and eventually functional impairment of related anatomic structures Imaging modalities for evaluating entheseal lesions include conventional radiology bone scintigraphy magnetic resonance imaging MRI and power Doppler PD ultrasound US US has its own unique advantage in the diagnosis of enthesitis in AS it uses a high-frequency or ultra-high-frequency probe that effectively visualizes the internal structure of the tendon and is recognized as the gold standard for tendon involvement
It is superior to clinical examination in the detection of peripheral enthesitis
Manifestations of tendon enthesitis in SpA on US include a thickened tendon hypoechoicity local calcification and bony erosion Abnormal blood flow in tendon entheseal sites can be detected by Power Doppler US Fibromyalgia FM is a syndrome characterized by chronic musculoskeletal pain The main symptoms of which are muscle stiffness joint stiffness insomnia fatigue mood disorders cognitive dysfunction anxiety depression general sensitivity and the inability to carry out normal daily activities 8 9 It can also be associated with specific diseases such as infections diabetes rheumatic diseases and psychiatric or neurological disorders Smythe and Moldofsky later developed the name fibromyalgia after identifying pain points which are areas of severe tenderness These points are defined as areas of hyperalgesiaallodynia when a pressure of about 4 kg causes pain
It is superior to clinical examination in the detection of peripheral enthesitis
Manifestations of tendon enthesitis in SpA on US include a thickened tendon hypoechoicity local calcification and bony erosion Abnormal blood flow in tendon entheseal sites can be detected by Power Doppler US Fibromyalgia FM is a syndrome characterized by chronic musculoskeletal pain The main symptoms of which are muscle stiffness joint stiffness insomnia fatigue mood disorders cognitive dysfunction anxiety depression general sensitivity and the inability to carry out normal daily activities 8 9 It can also be associated with specific diseases such as infections diabetes rheumatic diseases and psychiatric or neurological disorders Smythe and Moldofsky later developed the name fibromyalgia after identifying pain points which are areas of severe tenderness These points are defined as areas of hyperalgesiaallodynia when a pressure of about 4 kg causes pain
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None