Ignite Creation Date:
2024-07-17 @ 10:45 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06493422
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-10
First Post:
2024-06-18
Brief Title:
Online Interplay Between Deciding and Acting With Mild Cognitive Impairment
Sponsor:
University of Delaware
Organization:
University of Delaware
Study Overview
Official Title:
Online Interplay Between Deciding and Acting With Mild Cognitive Impairment
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators aim to understand the interplay and neural structures involved with decision--making and movement for participants with mild cognitive impairment Rapidly deciding and acting becomes bottlenecked with mild cognitive impairment and Alzheimers leading to detrimental outcomes such as falling and car crashes The investigators work will have a tangible impact by discovering sensitive biomarkers to detect disease onset and pave the way for informed and effective neurorehabilitation
Detailed Description:
Mild cognitive impairment leads not only to impaired decision making but also movement deficits that predict the development of Alzheimers disease Recent behavioral work has suggested a common mechanism that throttles the speed of both decisions and reaching movements which is supported by converging neural evidence that finds an interac-tion between decision making and movement motor circuits Yet it remains unknown how the interplay between decision making and motor neural circuits becomes impaired and impedes rapid responses for those with mild cognitive impairment Here the investigators test the central hypothesis that there is an impaired interaction between decision making and motor neural circuits with mild cognitive impairment
First the investigators will use human reaching experiments to establish that mild cognitive impairment disrupts the interplay of decision making and motor control Second the investigators will use Magnetic resonance elastography to elucidate whether brain stiffness in decision making and motor brain regions are related to altered movement behavior The expected outcome is a mechanistic understanding of how impaired decision making and motor neural circuits impact movement for those with mild cognitive impairment
First the investigators will use human reaching experiments to establish that mild cognitive impairment disrupts the interplay of decision making and motor control Second the investigators will use Magnetic resonance elastography to elucidate whether brain stiffness in decision making and motor brain regions are related to altered movement behavior The expected outcome is a mechanistic understanding of how impaired decision making and motor neural circuits impact movement for those with mild cognitive impairment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| U54GM104941 | NIH | None | None |