Ignite Creation Date:
2024-07-17 @ 10:48 AM
Last Modification Date:
2024-10-26 @ 3:33 PM
Study NCT ID:
NCT06478667
Status:
RECRUITING
Last Update Posted:
2024-06-27
First Post:
2024-06-23
Brief Title:
The Role of Levosimendan as Inotropic Agent in Acute Aluminum Phosphide-induced Cardiotoxicity
Sponsor:
Ain Shams University
Organization:
Ain Shams University
Study Overview
Official Title:
The Role of Levosimendan as Inotropic Agent in Acute Aluminum Phosphide-induced Cardiotoxicity A Randomized Controlled Trial
Status:
RECRUITING
Status Verified Date:
2024-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To evaluate the potential role of levosimendan as an inotropic agent in aluminum phosphide-induced cardiotoxicity
Detailed Description:
Aluminum phosphide ALP is a well-known fumigant known also as rice pill or wheat pill It is considered an ideal pesticide since it is effective to preserve stored grains against insects and rodents without leaving residues in addition to its availability and low cost In Egypt it has become a common method of suicide over the last few years because it is cheap and easily accessible Cardiomyocytes are one of the main targets for ALP ALP-induced cardiotoxicity involves detrimental effects such as direct myocardial tissue damage hypoperfusion myocarditis pericarditis and arrhythmias leading to circulatory failure Levosimendan an inotropic agent enhances cardiac contractility through calcium sensitization with minimal oxygen demand and in turn decreases the risk of arrhythmia However limited studies have investigated the role of levosimendan in the treatment of ALP induced cardiotoxicity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None