Ignite Creation Date:
2024-07-17 @ 10:48 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06490146
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-08
First Post:
2024-06-28
Brief Title:
Menopause Transition Sex Hormone Deficiency and Autonomic and Vascular Function
Sponsor:
University of Minnesota
Organization:
University of Minnesota
Study Overview
Official Title:
Menopause Transition Sex Hormone Deficiency and Autonomic and Vascular Function
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This is a longitudinal study to determine the influence of the menopause transition on autonomic and vascular function PI Keller-Ross has published data demonstrating that postmenopausal females have greater sympathetic neural reactivity during a stressor compared with age-matched males and younger females and males A paucity of literature exists however on the role of the menopause transition in autonomic function because the majority of experimental studies on menopause physiology are cross-sectional andor focused on older postmenopausal females
The influence of age on HTN is robust whereas the effects of menopause are still unclear Preliminary data demonstrate a clear association between age and sympathetic activity in females how the transition through menopause influences these relations however remains unknown The study will enroll 80 midlife 45-55 years of age females to measure longitudinally the trajectory of autonomic and vascular function during the transition through menopause The study hypothesizes that through the menopause transition an increase in sympathetic activity and an impaired baroreflex sensitivity and endothelial function will emerge
The influence of age on HTN is robust whereas the effects of menopause are still unclear Preliminary data demonstrate a clear association between age and sympathetic activity in females how the transition through menopause influences these relations however remains unknown The study will enroll 80 midlife 45-55 years of age females to measure longitudinally the trajectory of autonomic and vascular function during the transition through menopause The study hypothesizes that through the menopause transition an increase in sympathetic activity and an impaired baroreflex sensitivity and endothelial function will emerge
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None