Ignite Creation Date:
2024-07-17 @ 10:48 AM
Last Modification Date:
2024-10-26 @ 3:34 PM
Study NCT ID:
NCT06492252
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-09
First Post:
2024-07-01
Brief Title:
Speech Motor Learning and Retention Aim 3
Sponsor:
Yale University
Organization:
Yale University
Study Overview
Official Title:
Sensorimotor Basis of Speech Motor Learning and Retention
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The overall goal of this research is to test a new model of speech motor learning whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well The strategy for the proposed research is to identify individual brain areas that contribute causally to retention by disrupting their activity with transcranial magnetic stimulation TMS Investigators will also use functional magnetic resonance imaging fMRI which will enable identification of circuit-level activity which predicts either learning or retention of new movements and hence test the specific contributions of candidate sensory and motor zones In other studies investigators will record sensory and motor evoked potentials over the course of learning to determine the temporal order in which individual sensory and cortical motor regions contribute The goal here is to identify brain areas in which learning-related plasticity occurs first and which among these areas predict subsequent learning
Detailed Description:
The focus of this registration is Aim 3 Excitability will be assessed In Aim 3 resting-state fMRI will be interleaved with speech motor adaptation again using Harvard Sentences Additional scans and retention tests will be conducted 24 hours later to assess motor memory consolidation
The Speech Motor Learning and Retention Master Protocol is NCT06467292
The Speech Motor Learning and Retention Master Protocol is NCT06467292
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1R01DC022097-01A1 | OTHER_GRANT | None | None |